Cannabis Extract Composition Determines Reinforcement in a Vapor Self-Administration Paradigm

Abstract

The legalization of cannabis and shifting cultural attitudes have driven an increase in cannabis use and the proliferation of vapor delivery devices. The DSM-V recognizes “cannabis use disorder” under the umbrella of substance use disorders, but its neural mechanisms require greater clarity (Peters et al., 2020). Debate in the scientific community and the public sphere alike primarily asks, “is cannabis addictive?” and “are there negative effects from chronic use?” The first issue magnifies the second: if users compulsively seek cannabis or become dependent, then safe regimens become difficult to maintain.