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Synaptic Pruning in Schizophrenia: Does Minocycline Modulate Psychosocial Brain Development?

Jones, Michael C. and Koh, Jin Ming and Cheong, Kang Hao (2020) Synaptic Pruning in Schizophrenia: Does Minocycline Modulate Psychosocial Brain Development? Bioessays, 42 (9). Art. No. 2000046. ISSN 0265-9247. https://resolver.caltech.edu/CaltechAUTHORS:20200813-094025754

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Abstract

Recent studies suggest that the tetracycline antibiotic minocycline, or its cousins, hold therapeutic potential for affective and psychotic disorders. This is proposed on the basis of a direct effect on microglia‐mediated frontocortical synaptic pruning (FSP) during adolescence, perhaps in genetically susceptible individuals harboring risk alleles in the complement component cascade that is involved in this normal process of CNS circuit refinement. In reviewing this field, it is argued that minocycline is actually probing and modulating a deeply evolved and intricate system wherein psychosocial stimuli sculpt the circuitry of the “social brain” underlying adult behavior and personality. Furthermore, this system can generate psychiatric morbidity that is not dependent on genetic variation. This view has important ramifications for understanding “pathologies” of human social behavior and cognition as well as providing long‐sought potential mechanistic links between social experience and susceptibility to mental and physical disease.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1002/bies.202000046DOIArticle
ORCID:
AuthorORCID
Koh, Jin Ming0000-0002-6130-5591
Cheong, Kang Hao0000-0002-4475-5451
Additional Information:© 2020 Wiley. Issue Online: 25 August 2020; Version of Record online: 30 July 2020; Manuscript revised: 29 May 2020; Manuscript received: 05 March 2020. This project was supported by the Singapore University of Technology and Design Start‐up Research Grant (SRG SCI 2019 142). The authors declare no conflict of interest.
Funders:
Funding AgencyGrant Number
Singapore University of Technology and DesignSRG SCI 2019 142
Subject Keywords:drugs and controlled; electronic health records; mental health; microglia; minocycline; schizophrenia; substances
Issue or Number:9
Record Number:CaltechAUTHORS:20200813-094025754
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200813-094025754
Official Citation:Jones, M. C., Koh, J. M., Cheong, K. H., Synaptic Pruning in Schizophrenia: Does Minocycline Modulate Psychosocial Brain Development?. BioEssays 2020, 42, 2000046. https://doi.org/10.1002/bies.202000046
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:104950
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:13 Aug 2020 18:25
Last Modified:27 Aug 2020 22:57

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