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Finger-powered fluidic actuation and mixing via MultiJet 3D printing

Sweet, Eric and Mehta, Rudra and Xu, Yifan and Jew, Ryan and Lin, Rachel and Lin, Liwei (2020) Finger-powered fluidic actuation and mixing via MultiJet 3D printing. Lab on a Chip, 20 (18). pp. 3375-3385. ISSN 1473-0197. https://resolver.caltech.edu/CaltechAUTHORS:20200818-151255966

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Abstract

Additive manufacturing, or three-dimensional (3D) printing, has garnered significant interest in recent years towards the fabrication of sub-millimeter scale devices for an ever-widening array of chemical, biological and biomedical applications. Conventional 3D printed fluidic systems, however, still necessitate the use of non-portable, high-powered external off-chip sources of fluidic actuation, such as electro-mechanical pumps and complex pressure-driven controllers, thus limiting their scope towards point-of-need applications. This work proposes entirely 3D printed sources of human-powered fluidic actuation which can be directly incorporated into the design of any 3D printable sub-millifluidic or microfluidic system where electrical power-free operation is desired. Multiple modular, single-fluid finger-powered actuator (FPA) designs were fabricated and experimentally characterized. Furthermore, a new 3D fluidic one-way valve concept employing a dynamic bracing mechanism was developed, demonstrating a high diodicity of ∼1117.4 and significant reduction in back-flow from the state-of-the-art. As a result, fabricated FPA prototypes achieved tailorable experimental fluid flow rates from ∼100 to ∼3000 μL min−1 without the use of electricity. Moreover, a portable human-powered two-fluid pulsatile fluidic mixer, capable of generating fully-mixed fluids in 10 seconds, is presented, demonstrating the application of FPAs towards on-chip integration into more complex 3D printed fluidic networks.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1039/d0lc00488jDOIArticle
ORCID:
AuthorORCID
Sweet, Eric0000-0002-2916-467X
Additional Information:© Royal Society of Chemistry 2020. Submitted 12 May 2020; Accepted 31 Jul 2020; First published 04 Aug 2020. We would like to thank Jacqueline Elwood, Ilbey Karakurt and the other graduate and undergraduate members of the Micro Mechanical Methods for Biology (M3B) Research Program for their help with this project. Additionally, we thank Professor Robert Full of the Center for Interdisciplinary Biological Inspiration in Education and Research (CiBER) at UC Berkeley for the use of his Projet 3000 3D printer. This project was funded through the Berkeley Sensors and Actuators Center (BSAC) at UC Berkeley. Author contributions: E. S., R. M. and Y. X. conceived and designed the experiments; E. S., R. M., Y. X. and R. L. performed the experiments; E. S., R. M. and R. J. analyzed the data; E. S. wrote the manuscript; L. L. supervised the project and edited the manuscript. The authors declare no conflict of interest.
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Funding AgencyGrant Number
University of California, BerkeleyUNSPECIFIED
Issue or Number:18
Record Number:CaltechAUTHORS:20200818-151255966
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200818-151255966
Official Citation:Finger-powered fluidic actuation and mixing via MultiJet 3D printing. Lab Chip, 2020, 20, 3375-3385; doi: 10.1039/d0lc00488j
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:105014
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:19 Aug 2020 19:55
Last Modified:18 Sep 2020 16:02

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