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Decoding stimulus identity from multi-unit activity and local field potentials along the ventral auditory stream in the awake primate: implications for cortical neural prostheses

Smith, Elliot and Kellis, Spencer and House, Paul and Greger, Bradley (2013) Decoding stimulus identity from multi-unit activity and local field potentials along the ventral auditory stream in the awake primate: implications for cortical neural prostheses. Journal of Neural Engineering, 10 (1). Art. No. 016010. ISSN 1741-2560. PMCID PMC3602219. doi:10.1088/1741-2560/10/1/016010. https://resolver.caltech.edu/CaltechAUTHORS:20200825-070041257

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Abstract

Objective. Hierarchical processing of auditory sensory information is believed to occur in two streams: a ventral stream responsible for stimulus identity and a dorsal stream responsible for processing spatial elements of a stimulus. The objective of the current study is to examine neural coding in this processing stream in the context of understanding the possibility for an auditory cortical neural prosthesis. Approach. We examined the selectivity for species-specific primate vocalizations in the ventral auditory processing stream by applying a statistical classifier to neural data recorded from microelectrode arrays. Multi-unit activity (MUA) and local field potential (LFP) data recorded simultaneously from primary auditory complex (AI) and rostral parabelt (PBr) were decoded on a trial-by-trial basis. Main results. While decode performance in AI was well above chance, mean performance in PBr did not deviate >15% from chance level. Mean performance levels were similar for MUA and LFP decodes. Increasing the spectral and temporal resolution improved decode performance; while inter-electrode spacing could be as large as 1.14 mm without degrading decode performance. Significance. These results serve as preliminary guidance for a human auditory cortical neural prosthesis; instructing interface implementation, microstimulation patterns and anatomical placement.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1088/1741-2560/10/1/016010DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602219PubMed CentralArticle
ORCID:
AuthorORCID
Kellis, Spencer0000-0002-5158-1058
Greger, Bradley0000-0002-6702-7596
Additional Information:© 2013 IOP Publishing Ltd. Received 22 August 2012; Accepted for publication 29 November 2012; Published 3 January 2013. An NIH NIDCD 5 T32 DC008553-02 training grant and University of Utah startup funds supported this work.
Funders:
Funding AgencyGrant Number
NIH Predoctoral Fellowship5 T32 DC008553-02
University of UtahUNSPECIFIED
Issue or Number:1
PubMed Central ID:PMC3602219
DOI:10.1088/1741-2560/10/1/016010
Record Number:CaltechAUTHORS:20200825-070041257
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200825-070041257
Official Citation:Elliot Smith et al 2013 J. Neural Eng. 10 016010
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:105090
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:25 Aug 2020 15:52
Last Modified:16 Nov 2021 18:39

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