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Complex Organization of Human Primary Motor Cortex: A High-Resolution fMRI Study

Meier, Jeffrey D. and Aflalo, Tyson N. and Kastner, Sabine and Graziano, Michael S. A. (2008) Complex Organization of Human Primary Motor Cortex: A High-Resolution fMRI Study. Journal of Neurophysiology, 100 (4). pp. 1800-1812. ISSN 0022-3077. PMCID PMC2576195. doi:10.1152/jn.90531.2008.

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A traditional view of the human motor cortex is that it contains an overlapping sequence of body part representations from the tongue in a ventral location to the foot in a dorsal location. In this study, high-resolution functional MRI (1.5 × 1.5 × 2 mm) was used to examine the somatotopic map in the lateral motor cortex of humans, to determine whether it followed the traditional somatotopic order or whether it contained any violations of that somatotopic order. The arm and hand representation had a complex organization in which the arm was relatively emphasized in two areas: one dorsal and the other ventral to a region that emphasized the fingers. This violation of a traditional somatotopic order suggests that the motor cortex is not merely a map of the body but is topographically shaped by other influences, perhaps including correlations in the use of body parts in the motor repertoire.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Aflalo, Tyson N.0000-0002-0101-2455
Kastner, Sabine0000-0001-6430-6154
Graziano, Michael S. A.0000-0002-7727-3475
Additional Information:© 2008 by the American Physiological Society. Received 5 May 2008; Accepted 29 July 2008; Published online 1 October 2008; Published in print 1 October 2008. We thank M. Harvey and S. Szczepanski for help in running subjects and analyzing data and T. Mole for comments on the manuscript. This work was supported by National Institutes of Health Grants R01 NS-046407, R01 MH-64043, and P50 MH-62196. The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
Funding AgencyGrant Number
NIHR01 NS-046407
NIHR01 MH-64043
NIHP50 MH-62196
Issue or Number:4
PubMed Central ID:PMC2576195
Record Number:CaltechAUTHORS:20200826-074350958
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Official Citation:Complex Organization of Human Primary Motor Cortex: A High-Resolution fMRI Study. Jeffrey D. Meier, Tyson N. Aflalo, Sabine Kastner, and Michael S. A. Graziano. Journal of Neurophysiology 2008 100:4, 1800-1812; doi: 10.1152/jn.90531.2008
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:105111
Deposited By: Tony Diaz
Deposited On:26 Aug 2020 16:00
Last Modified:16 Nov 2021 18:39

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