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Coronavirus Disease 2019 Patients in Earlier Stages Exhaled Millions of Severe Acute Respiratory Syndrome Coronavirus 2 Per Hour

Ma, Jianxin and Qi, Xiao and Chen, Haoxuan and Li, Xinyue and Zhang, Zheng and Wang, Haibin and Sun, Lingli and Zhang, Lu and Guo, Jiazhen and Morawska, Lidia and Grinshpun, Sergey A. and Biswas, Pratim and Flagan, Richard C. and Yao, Maosheng (2020) Coronavirus Disease 2019 Patients in Earlier Stages Exhaled Millions of Severe Acute Respiratory Syndrome Coronavirus 2 Per Hour. Clinical Infectious Diseases . ISSN 1058-4838. (In Press) https://resolver.caltech.edu/CaltechAUTHORS:20200909-135124154

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Abstract

Coronavirus disease 2019 (COVID-19) patients exhaled millions of severe acute respiratory syndrome coronavirus 2 RNA copies per hour, which plays an important role in COVID-19 transmission. Exhaled breath had a higher positive rate (26.9%, n = 52) than surface (5.4%, n = 242) and air (3.8%, n = 26) samples.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1093/cid/ciaa1283DOIArticle
https://doi.org/10.1101/2020.05.31.20115154DOIDiscussion Paper
ORCID:
AuthorORCID
Chen, Haoxuan0000-0001-8398-9093
Li, Xinyue0000-0002-0822-4960
Morawska, Lidia0000-0002-0594-9683
Grinshpun, Sergey A.0000-0003-4339-927X
Biswas, Pratim0000-0003-1104-3738
Flagan, Richard C.0000-0001-5690-770X
Yao, Maosheng0000-0002-1442-8054
Alternate Title:Exhaled breath is a significant source of SARS-CoV-2 emission, COVID-19 patients in earlier stages exhaled millions of SARS-CoV-2 per hour
Additional Information:© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model). Received: 15 July 2020; Editorial decision: 24 August 2020; Accepted: 26 August 2020; Published: 28 August 2020; Corrected and typeset: 08 October 2020. The authors thank the local Center for Disease Prevention and Control medical stuff for their assistance in recruiting patients. This research was supported by the National Natural Science Foundation of China (NSFC; 22040101) and the NSFC Distinguished Young Scholars Fund (21725701 to M. Y.). Author contributions. M. Y. and J. M. contributed to the study design. J. M., M. Y., X. Q., Z. Z., H. W., L. S., and J. G. contributed to sample collection and experiments. J. M., X. Q., and M. Y. contributed to patients’ recruitment and clinical management. M. Y., J. M., X. L., H. C., L. Z., L. M., S. A. G., P. B., and R. C. F. contributed to data analysis, data interpretation, figure preparation, and literature search. M. Y. wrote the manuscript draft, and all authors revised the manuscript. All authors reviewed and approved the final version of the report. Potential conflicts of interest. The authors: No reported conflicts of interest. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest.
Funders:
Funding AgencyGrant Number
National Natural Science Foundation of China22040101
National Natural Science Foundation of China21725701
Subject Keywords:COVID-19, SARS-CoV-2, exhaled breath, airborne transmission
Record Number:CaltechAUTHORS:20200909-135124154
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200909-135124154
Official Citation:Jianxin Ma, Xiao Qi, Haoxuan Chen, Xinyue Li, Zheng Zhang, Haibin Wang, Lingli Sun, Lu Zhang, Jiazhen Guo, Lidia Morawska, Sergey A Grinshpun, Pratim Biswas, Richard C Flagan, Maosheng Yao, Coronavirus Disease 2019 Patients in Earlier Stages Exhaled Millions of Severe Acute Respiratory Syndrome Coronavirus 2 Per Hour, Clinical Infectious Diseases, , ciaa1283, https://doi.org/10.1093/cid/ciaa1283
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:105297
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:09 Sep 2020 22:03
Last Modified:20 Nov 2020 16:50

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