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Feedback from retinal ganglion cells to the inner retina

Vlasiuk, Anastasiia and Asari, Hiroki (2020) Feedback from retinal ganglion cells to the inner retina. . (Unpublished)

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Retinal ganglion cells (RGCs) are thought to be strictly postsynaptic within the retina. They carry visual signals from the eye to the brain, but do not make chemical synapses onto other retinal neurons. Nevertheless, they form gap junctions with other RGCs and amacrine cells, providing possibilities for RGC signals to feed back into the inner retina. Here we identified such feedback circuitry in the salamander and mouse retinas. First, using biologically inspired circuit models, we found mutual inhibition among RGCs of the same type. We then experimentally determined that this effect is mediated by gap junctions with amacrine cells. Finally, we found that this negative feedback lowers RGC visual response gain without affecting feature selectivity. The principal neurons of the retina therefore participate in a recurrent circuit much as those in other brain areas, not being a mere collector of retinal signals, but are actively involved in visual computations.

Item Type:Report or Paper (Discussion Paper)
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URLURL TypeDescription Paper
Vlasiuk, Anastasiia0000-0001-6089-7487
Additional Information:The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. Version 1 August 31, 2020; Version 2 - January 18, 2021; Version 3 - June 5, 2021. This work was supported by Gosney Postdoctoral Fellowship from CalTech and research grants from EMBL (H.A.). We gratefully acknowledge Markus Meister for assistance with experiments. We also thank all the members of the Asari lab at EMBL Rome as well as Cornelius Gross and Santiago Rompani for many useful discussions. Author contributions: A.V. and H.A. designed the study, performed the experiments, analyzed the results, and wrote the manuscript. The authors have declared no competing interest.
Funding AgencyGrant Number
Caltech Gosney FellowshipUNSPECIFIED
European Molecular Biology Laboratory (EMBL)UNSPECIFIED
Subject Keywords:Retinal ganglion cell, gap junction, feedback, circuit model, gain control
Record Number:CaltechAUTHORS:20200909-151324927
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Official Citation:Feedback from retinal ganglion cells to the inner retina. Anastasiia Vlasiuk, Hiroki Asari. bioRxiv 2020.08.30.274514; doi:
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:105303
Deposited By: Tony Diaz
Deposited On:09 Sep 2020 23:13
Last Modified:16 Nov 2021 18:41

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