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Thermoplasmonic Optical Fiber for Localized Neural Stimulation

Kang, Hongki and Hong, Woongki and An, Yujin and Yoo, Sangjin and Kwon, Hyuk-Jun and Nam, Yoonkey (2020) Thermoplasmonic Optical Fiber for Localized Neural Stimulation. ACS Nano, 14 (9). pp. 11406-11419. ISSN 1936-0851. https://resolver.caltech.edu/CaltechAUTHORS:20200911-133127491

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Abstract

Thermoplasmonic effect-based neural stimulation has been suggested as an alternative optical neural stimulation technology without genetic modification. Integration of near-infrared light with plasmonic gold nanoparticles has been demonstrated as a neuromodulation tool on in vitro neuronal network models. In order to further test the validity of the thermoplasmonic neural stimulation across multiple biological models (in vitro, ex vivo, and in vivo) avoiding genetic modification in optical neuromodulation, versatile engineering approaches to apply the thermoplasmonic effect would be required. In this work, we developed a gold nanorod attached optical fiber technology for the localized neural stimulation based on a thermoplasmonic effect. A simple fabrication process was developed for efficient nanoparticle coating on commercial optical fibers. The thermoplasmonic optical fiber proved that it can locally modulate the neural activity in vitro. Lastly, we simulated the spatiotemporal temperature change by the thermoplasmonic optical fiber and analyzed its applicability to in vivo animal models.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1021/acsnano.0c03703DOIArticle
ORCID:
AuthorORCID
Kang, Hongki0000-0002-6729-5486
Yoo, Sangjin0000-0002-0449-4242
Nam, Yoonkey0000-0003-4801-9547
Alternate Title:Thermo-Plasmonic Optical Fiber for Localized Neural Stimulation
Additional Information:© 2020 American Chemical Society. Received: May 4, 2020; Accepted: September 4, 2020;Published: September 4, 2020. This work was supported both by the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (NRF- 2018R1A2A1A05022604) and by the DGIST R&D Program of the Ministry of Science and ICT (19-CoE-BT-03). The authors declare no competing financial interest.
Funders:
Funding AgencyGrant Number
National Research Foundation of KoreaNRF-2018R1A2A1A05022604
Ministry of Science, ICT and Future Planning (Korea)19-CoE-BT-03
Subject Keywords:optical neural stimulation, neuromodulation, thermoplasmonics, photothermal effect, optical fiber, gold nanorod, microelectrode array
Issue or Number:9
Record Number:CaltechAUTHORS:20200911-133127491
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200911-133127491
Official Citation:Thermoplasmonic Optical Fiber for Localized Neural Stimulation. Hongki Kang, Woongki Hong, Yujin An, Sangjin Yoo, Hyuk-Jun Kwon, and Yoonkey Nam. ACS Nano 2020 14 (9), 11406-11419; DOI: 10.1021/acsnano.0c03703
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:105323
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:11 Sep 2020 21:48
Last Modified:23 Sep 2020 16:47

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