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A Spectrum of Cell States During the Epithelial-to-Mesenchymal Transition

Hutchins, Erica J. and Bronner, Marianne E. (2020) A Spectrum of Cell States During the Epithelial-to-Mesenchymal Transition. In: The Epithelial-to Mesenchymal Transition: Methods and Protocols. Methods in Molecular Biology. No.2179. Humana Press , New York, NY, pp. 3-6. ISBN 978-1-0716-0778-7. https://resolver.caltech.edu/CaltechAUTHORS:20200923-121742113

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Abstract

The epithelial-to-mesenchymal transition (EMT) encompasses a complex cascade of events through which a cell transits to reduce its epithelial characteristics and become migratory. Classically, this transition has been considered complete upon loss of molecular markers characteristic of an “epithelial” state and acquisition of those associated with “mesenchymal” cells. Recently, however, evidence from both developmental and cancer EMT contexts suggest that cells undergoing EMT are often heterogeneous, concomitantly expressing both epithelial and mesenchymal markers to varying degrees; rather, cells frequently display a “partial” EMT phenotype and do not necessarily require full “mesenchymalization” to become migratory. Here, we offer a brief perspective on recent important advances in our fundamental understanding of the spectrum of cellular states that occur during partial EMT in the context of development and cancer metastasis.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1007/978-1-0716-0779-4_1DOIArticle
ORCID:
AuthorORCID
Hutchins, Erica J.0000-0002-4316-0333
Bronner, Marianne E.0000-0003-4274-1862
Additional Information:© 2021 Springer Science+Business Media, LLC, part of Springer Nature. First Online: 17 September 2020.
Subject Keywords:Epithelial-to-mesenchymal transition; Partial EMT; Cancer; Post-transcriptional regulation; Heterogeneity
Series Name:Methods in Molecular Biology
Issue or Number:2179
Record Number:CaltechAUTHORS:20200923-121742113
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200923-121742113
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:105491
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:23 Sep 2020 19:27
Last Modified:23 Sep 2020 19:27

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