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Enhancing peripheral nerve regeneration with neurotrophic factors and bioengineered scaffolds: A basic science and clinical perspective

Lien, Brian V. and Brown, Nolan J. and Ransom, Seth C. and Lehrich, Brandon M. and Shahrestani, Shane and Tafreshi, Ali R. and Ransom, Ryan C. and Sahyouni, Ronald (2020) Enhancing peripheral nerve regeneration with neurotrophic factors and bioengineered scaffolds: A basic science and clinical perspective. Journal of the Peripheral Nervous System . ISSN 1085-9489. (In Press) https://resolver.caltech.edu/CaltechAUTHORS:20200924-144350749

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Abstract

Despite the peripheral nervous system's (PNS) capacity to regenerate, functional restoration is highly variable following peripheral nerve injury (PNI), oftentimes leading to persistent functional deficits. In the preclinical arena, advances in the therapeutic use of exogenous neurotrophic factors and synthetic neural scaffold technology hold promise in augmenting endogenous PNS regeneration following PNI. Clinical trials utilizing neurotrophic factors for other indications (eg, peripheral neuropathy) may provide insight into their role in PNI. Here we provide an updated review of progress made towards enhancing regeneration after PNI with a focus on neurotrophic factors and bioengineered scaffolds.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1111/jns.12414DOIArticle
ORCID:
AuthorORCID
Lien, Brian V.0000-0003-3044-8626
Shahrestani, Shane0000-0001-7561-4590
Tafreshi, Ali R.0000-0002-8956-3373
Sahyouni, Ronald0000-0002-2124-0535
Additional Information:© 2020 Peripheral Nerve Society. Accepted manuscript online: 16 September 2020. Manuscript accepted: 07 September 2020. Manuscript revised: 05 September 2020. Manuscript received: 15 August 2020.
Subject Keywords:bioengineered scaffolds; neural scaffolds; neurotrophic factors; peripheral nerve injury; peripheral nerve regeneration; peripheral nerve repair
Record Number:CaltechAUTHORS:20200924-144350749
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200924-144350749
Official Citation:Lien, BV, Brown, NJ, Ransom, SC, et al. Enhancing peripheral nerve regeneration with neurotrophic factors and bioengineered scaffolds: A basic science and clinical perspective. J Peripher Nerv Syst. 2020; 1–15. https://doi.org/10.1111/jns.12414
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:105521
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:25 Sep 2020 01:23
Last Modified:25 Sep 2020 01:23

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