Lien, Brian V. and Brown, Nolan J. and Ransom, Seth C. and Lehrich, Brandon M. and Shahrestani, Shane and Tafreshi, Ali R. and Ransom, Ryan C. and Sahyouni, Ronald (2020) Enhancing peripheral nerve regeneration with neurotrophic factors and bioengineered scaffolds: A basic science and clinical perspective. Journal of the Peripheral Nervous System, 25 (4). pp. 320-334. ISSN 1085-9489. doi:10.1111/jns.12414. https://resolver.caltech.edu/CaltechAUTHORS:20200924-144350749
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Abstract
Despite the peripheral nervous system's (PNS) capacity to regenerate, functional restoration is highly variable following peripheral nerve injury (PNI), oftentimes leading to persistent functional deficits. In the preclinical arena, advances in the therapeutic use of exogenous neurotrophic factors and synthetic neural scaffold technology hold promise in augmenting endogenous PNS regeneration following PNI. Clinical trials utilizing neurotrophic factors for other indications (eg, peripheral neuropathy) may provide insight into their role in PNI. Here we provide an updated review of progress made towards enhancing regeneration after PNI with a focus on neurotrophic factors and bioengineered scaffolds.
| Item Type: | Article | ||||||||||||||||||
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| Additional Information: | © 2020 Peripheral Nerve Society. Accepted manuscript online: 16 September 2020. Manuscript accepted: 07 September 2020. Manuscript revised: 05 September 2020. Manuscript received: 15 August 2020. | ||||||||||||||||||
| Subject Keywords: | bioengineered scaffolds; neural scaffolds; neurotrophic factors; peripheral nerve injury; peripheral nerve regeneration; peripheral nerve repair | ||||||||||||||||||
| Issue or Number: | 4 | ||||||||||||||||||
| DOI: | 10.1111/jns.12414 | ||||||||||||||||||
| Record Number: | CaltechAUTHORS:20200924-144350749 | ||||||||||||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20200924-144350749 | ||||||||||||||||||
| Official Citation: | Lien, BV, Brown, NJ, Ransom, SC, et al. Enhancing peripheral nerve regeneration with neurotrophic factors and bioengineered scaffolds: A basic science and clinical perspective. J Peripher Nerv Syst. 2020; 25: 320–334. https://doi.org/10.1111/jns.12414 | ||||||||||||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||||||||||
| ID Code: | 105521 | ||||||||||||||||||
| Collection: | CaltechAUTHORS | ||||||||||||||||||
| Deposited By: | George Porter | ||||||||||||||||||
| Deposited On: | 25 Sep 2020 01:23 | ||||||||||||||||||
| Last Modified: | 16 Nov 2021 18:43 |
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