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Tumor Necrosis Factor:A Potent Mediator of Macrophage-Dependent Tumor-Cell Killing

Urban, J. L. and Rothstein, J. L. and Shephard, M. H. and Schreiber, H. (1987) Tumor Necrosis Factor:A Potent Mediator of Macrophage-Dependent Tumor-Cell Killing. In: Modern Trends in Human Leukemia VII: New Results in Clinical and Biological Research Including Pediatric Oncolog. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion. No.31. Springer , Berlin, pp. 351-354. ISBN 978-3-540-17754-8.

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Macrophages (Mφ) can be activated to show highly selective cytotoxicity toward malignant cells in vitro [6, 8, 9, 13, 14] and there is some evidence that they may destroy neoplastic cells in vivo [1]. The importance of activated Mφ (aMφ) in controlling tumor growth in vivo has been further implicated in experiments involving murine ultraviolet light (UV)-induced tumors, which are highly immunogenic regressor tumors [10] sensitive to Mφ in vitro [22]. Variants of these tumors demonstrating progressive growth in the normal host were found to invariably express an increased resistance to aMφ [22]. Furthermore, exposure of regressor tumor cells to aMφ in vitro also resulted in selection for Mφ-resistant cancer cells which displayed an increased early growth potential in vivo [22]. More recently we have utilized these tumor variants resistant to aMφ to explore the mechanism by which aMφ induce tumor cell destruction [23].

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Additional Information:© 1987 Springer-Verlag Berlin Heidelberg. This work was supported by grants CA-22677, CA-19266, CA-37156, 5-T32 AI-07090, and 5-T32 GMO-7281 from the National Institutes of Health.
Funding AgencyGrant Number
NIH Predoctoral Fellowship5-T32 AI-07090
NIH Predoctoral Fellowship5-T32 GMO-7281
Subject Keywords:Control Tumor Growth; Tumor Variant; Tumor Cytotoxicity; Frederick Cancer Research; Regressor Tumor
Series Name:Haematology and Blood Transfusion / Hämatologie und Bluttransfusion
Issue or Number:31
Record Number:CaltechAUTHORS:20200924-154443392
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:105532
Deposited By: Tony Diaz
Deposited On:24 Sep 2020 23:04
Last Modified:16 Nov 2021 18:43

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