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The Centrioles, Centrosomes, Basal Bodies, and Cilia of Drosophila melanogaster

Lattao, Ramona and Kovacs, Levente and Glover, David M. (2017) The Centrioles, Centrosomes, Basal Bodies, and Cilia of Drosophila melanogaster. Genetics, 206 (1). pp. 33-53. ISSN 0016-6731. PMCID PMC5419478. doi:10.1534/genetics.116.198168. https://resolver.caltech.edu/CaltechAUTHORS:20200928-150624614

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Abstract

Centrioles play a key role in the development of the fly. They are needed for the correct formation of centrosomes, the organelles at the poles of the spindle that can persist as microtubule organizing centers (MTOCs) into interphase. The ability to nucleate cytoplasmic microtubules (MTs) is a property of the surrounding pericentriolar material (PCM). The centriole has a dual life, existing not only as the core of the centrosome but also as the basal body, the structure that templates the formation of cilia and flagellae. Thus the structure and functions of the centriole, the centrosome, and the basal body have an impact upon many aspects of development and physiology that can readily be modeled in Drosophila Centrosomes are essential to give organization to the rapidly increasing numbers of nuclei in the syncytial embryo and for the spatially precise execution of cell division in numerous tissues, particularly during male meiosis. Although mitotic cell cycles can take place in the absence of centrosomes, this is an error-prone process that opens up the fly to developmental defects and the potential of tumor formation. Here, we review the structure and functions of the centriole, the centrosome, and the basal body in different tissues and cultured cells of Drosophila melanogaster, highlighting their contributions to different aspects of development and cell division.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1534/genetics.116.198168DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5419478/PubMed CentralArticle
ORCID:
AuthorORCID
Lattao, Ramona0000-0002-1725-0175
Kovacs, Levente0000-0002-3226-3740
Glover, David M.0000-0003-0956-0103
Additional Information:© 2017 Lattao et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Received November 10, 2016. Accepted March 24, 2017. Published online May 5, 2017. We are very grateful to Hélène Rangone and Nick Dzhindzhev for their comments on the drafts of this article. Studies of centriole and basal body function in our laboratory are funded by the Wellcome Trust.
Funders:
Funding AgencyGrant Number
Wellcome TrustUNSPECIFIED
Subject Keywords:Drosophila; basal body; centriole; centrosome; cilia; FlyBook
Issue or Number:1
PubMed Central ID:PMC5419478
DOI:10.1534/genetics.116.198168
Record Number:CaltechAUTHORS:20200928-150624614
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20200928-150624614
Official Citation:The Centrioles, Centrosomes, Basal Bodies, and Cilia of Drosophila melanogaster Ramona Lattao, Levente Kovács and David M. Glover GENETICS May 1, 2017 vol. 206 no. 1 33-53; https://doi.org/10.1534/genetics.116.198168
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:105600
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:30 Sep 2020 15:55
Last Modified:16 Nov 2021 18:44

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