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Evidence for multiple structural genes for the γ chain of human fetal hemoglobin

Schroeder, W. A. and Huisman, T. H. J. and Shelton, J. Roger and Shelton, Joan Balog and Kleihauer, Enno F. and Dozy, Andrée M. and Robberson, Barbara (1968) Evidence for multiple structural genes for the γ chain of human fetal hemoglobin. Proceedings of the National Academy of Sciences of the United States of America, 60 (2). pp. 537-544. ISSN 0027-8424. PMCID PMC225081. doi:10.1073/pnas.60.2.537.

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A sequence with a specific residue at each position was proposed for the γ chain of human fetal hemoglobin by Schroeder et al. (1) after a study in which hemoglobin from a number of individual infants was used. We have now examined in part the fetal hemoglobin components of 17 additional infants and have observed that position 136 of the γ chain may be occupied not only by a glycyl residue, as previously reported, but also by an alanyl residue.

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Additional Information:© 1968 by the National Academy of Sciences. Communicated by Ray D. Owen, April 5, 1968. We appreciate the helpful discussions on genetics with Drs. E.B. Lewis and Ray D. Owen. Dr. Audrey Brown (Department of Pediatrics, Medical College of Georgia) assisted us in obtaining additional samples from babies D.P., W.B., and C.W. We are also indebted to Dr. Edgar Ahern (Department of Pathology, University College Hospital, Jamaica, W.I.) who made samples from baby J. B. available to us. Mr. Gerald Apell assisted in some of the experimental work. This investigation was supported in part by grants (HE-02558 and HE-05168) from the National Institutes of Health, U.S. Public Health Service. E.F.K. was supported by USPHS grant 1 FOS-TW-1127-01 as an International Research Fellow on leave from the Department of Pediatrics, University of Munich, Germany. Division of Chemistry and Chemical Engineering, Contribution no. 3668.
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NIH Postdoctoral Fellowship1 FOS-TW-1127-01
Issue or Number:2
PubMed Central ID:PMC225081
Record Number:CaltechAUTHORS:SCHRpnas68
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:10565
Deposited By: Tony Diaz
Deposited On:19 May 2008
Last Modified:08 Nov 2021 21:09

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