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SARS-CoV-2 RapidPlex: A Graphene-Based Multiplexed Telemedicine Platform for Rapid and Low-Cost COVID-19 Diagnosis and Monitoring

Torrente-Rodríguez, Rebeca M. and Lukas, Heather and Tu, Jiaobing and Min, Jihong and Yang, Yiran and Xu, Changhao and Rossiter, Harry B. and Gao, Wei (2020) SARS-CoV-2 RapidPlex: A Graphene-Based Multiplexed Telemedicine Platform for Rapid and Low-Cost COVID-19 Diagnosis and Monitoring. Matter, 3 (6). pp. 1981-1998. ISSN 2590-2385. PMCID PMC7535803. doi:10.1016/j.matt.2020.09.027.

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The COVID-19 pandemic is an ongoing global challenge for public health systems. Ultrasensitive and early identification of infection is critical in preventing widespread COVID-19 infection by presymptomatic and asymptomatic individuals, especially in the community and in-home settings. We demonstrate a multiplexed, portable, wireless electrochemical platform for ultra-rapid detection of COVID-19: the SARS-CoV-2 RapidPlex. It detects viral antigen nucleocapsid protein, IgM and IgG antibodies, as well as the inflammatory biomarker C-reactive protein, based on our mass-producible laser-engraved graphene electrodes. We demonstrate ultrasensitive, highly selective, and rapid electrochemical detection in the physiologically relevant ranges. We successfully evaluated the applicability of our SARS-CoV-2 RapidPlex platform with COVID-19-positive and COVID-19-negative blood and saliva samples. Based on this pilot study, our multiplexed immunosensor platform may allow for high-frequency at-home testing for COVID-19 telemedicine diagnosis and monitoring.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Tu, Jiaobing0000-0002-7653-6640
Min, Jihong0000-0002-5788-1473
Yang, Yiran0000-0001-8770-8746
Rossiter, Harry B.0000-0002-7884-0726
Gao, Wei0000-0002-8503-4562
Additional Information:© 2020 Elsevier Inc. Accepted: September 29, 2020; Received in revised form: September 20, 2020; Received: September 1, 2020. This project was supported by the Merkin Institute for Translational Research at Caltech, Emergency COVID-19 Research Seed Funding and COVID-19 Continuation Funding from Tobacco-Related Disease Research Program (TRDRP), TRDRP High Impact Pilot Research Award, National Institutes of Health (5R21NR018271), and the Translational Research Institute through NASA NNX16AO69A. J.T. was supported by the National Science Scholarship from the Agency for Science, Technology and Research (A∗STAR), Singapore. We gratefully acknowledge critical support and infrastructure provided for this work by the Kavli Nanoscience Institute at Caltech. Author Contributions: W.G., R.M.T.-R., and H.L. initiated the concept and designed the experiments; R.M.T.-R., H.L., and J.T. led the experiments and collected the overall data; Y.Y. performed electrode fabrication and characterization; J.M. performed the circuit design and platform test; C.X. contributed to sensor characterization; W.G., R.M.T.-R., and H.L. contributed the data analysis and co-wrote the paper. All authors provided the feedback on the manuscript. The authors declare no competing interests.
Group:Kavli Nanoscience Institute, Richard N. Merkin Institute for Translational Research, COVID-19
Funding AgencyGrant Number
Caltech Merkin Institute for Translational ResearchUNSPECIFIED
California Tobacco-Related Disease Research ProgramUNSPECIFIED
Agency for Science, Technology and Research (A*STAR)UNSPECIFIED
Issue or Number:6
PubMed Central ID:PMC7535803
Record Number:CaltechAUTHORS:20201002-102234974
Persistent URL:
Official Citation:Rebeca M. Torrente-Rodríguez, Heather Lukas, Jiaobing Tu, Jihong Min, Yiran Yang, Changhao Xu, Harry B. Rossiter, Wei Gao, SARS-CoV-2 RapidPlex: A Graphene-Based Multiplexed Telemedicine Platform for Rapid and Low-Cost COVID-19 Diagnosis and Monitoring, Matter, Volume 3, Issue 6, 2020, Pages 1981-1998, ISSN 2590-2385,
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:105754
Deposited By: Tony Diaz
Deposited On:02 Oct 2020 20:51
Last Modified:12 Feb 2022 00:59

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