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Cleavage furrow formation and ingression during animal cytokinesis: a microtubule legacy

D'Avino, Pier Paolo and Savoian, Matthew S. and Glover, David M. (2005) Cleavage furrow formation and ingression during animal cytokinesis: a microtubule legacy. Journal of Cell Science, 118 (8). pp. 1549-1558. ISSN 0021-9533. doi:10.1242/jcs.02335. https://resolver.caltech.edu/CaltechAUTHORS:20201002-140639832

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Abstract

Cytokinesis ensures the proper partitioning of the nuclear and cytoplasmic contents into independent daughter cells at the end of cell division. Although the metazoan mitotic spindle has been implicated in the placement and advancement of the cleavage furrow, the molecules responsible for these processes have remained elusive. Recent studies have provided insights into the role of different microtubule structures and associated proteins in cleavage furrow positioning and ingression together with the signalling events that regulate the dynamics of the equatorial cell cortex during cytokinesis. We try to unify these findings into a general model of cytokinesis in which both astral and central spindle microtubules have the ability to induce furrowing. We further propose that the evolutionarily conserved centralspindlin complex serves as a master controller of cell cleavage in Drosophila by promoting both furrow formation and ingression. The same mechanism might be conserved in other organisms.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1242/jcs.02335DOIArticle
ORCID:
AuthorORCID
D'Avino, Pier Paolo0000-0002-4773-6950
Savoian, Matthew S.0000-0002-2594-3879
Glover, David M.0000-0003-0956-0103
Additional Information:© The Company of Biologists Limited 2005. We thank two anonymous referees for helpful suggestions. Work in the D.M.G. laboratory is supported by Cancer Research UK, MRC and BBSRC.
Funders:
Funding AgencyGrant Number
Cancer Research UKUNSPECIFIED
Medical Research Council (UK)UNSPECIFIED
Biotechnology and Biological Sciences Research Council (BBSRC)UNSPECIFIED
Subject Keywords:Central spindle, Cleavage furrow, Contractile ring, Cytokinesis, Microtubules, Rho GTPases
Issue or Number:8
DOI:10.1242/jcs.02335
Record Number:CaltechAUTHORS:20201002-140639832
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20201002-140639832
Official Citation:Cleavage furrow formation and ingression during animal cytokinesis: a microtubule legacy Pier Paolo D'Avino, Matthew S. Savoian, David M. Glover Journal of Cell Science 2005 118: 1549-1558; doi: 10.1242/jcs.02335
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:105762
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:05 Oct 2020 16:24
Last Modified:16 Nov 2021 18:46

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