D'Avino, Pier Paolo and Savoian, Matthew S. and Glover, David M. (2005) Cleavage furrow formation and ingression during animal cytokinesis: a microtubule legacy. Journal of Cell Science, 118 (8). pp. 1549-1558. ISSN 0021-9533. doi:10.1242/jcs.02335. https://resolver.caltech.edu/CaltechAUTHORS:20201002-140639832
![]()
|
PDF
- Published Version
See Usage Policy. 224kB |
Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20201002-140639832
Abstract
Cytokinesis ensures the proper partitioning of the nuclear and cytoplasmic contents into independent daughter cells at the end of cell division. Although the metazoan mitotic spindle has been implicated in the placement and advancement of the cleavage furrow, the molecules responsible for these processes have remained elusive. Recent studies have provided insights into the role of different microtubule structures and associated proteins in cleavage furrow positioning and ingression together with the signalling events that regulate the dynamics of the equatorial cell cortex during cytokinesis. We try to unify these findings into a general model of cytokinesis in which both astral and central spindle microtubules have the ability to induce furrowing. We further propose that the evolutionarily conserved centralspindlin complex serves as a master controller of cell cleavage in Drosophila by promoting both furrow formation and ingression. The same mechanism might be conserved in other organisms.
Item Type: | Article | ||||||||
---|---|---|---|---|---|---|---|---|---|
Related URLs: |
| ||||||||
ORCID: |
| ||||||||
Additional Information: | © The Company of Biologists Limited 2005. We thank two anonymous referees for helpful suggestions. Work in the D.M.G. laboratory is supported by Cancer Research UK, MRC and BBSRC. | ||||||||
Funders: |
| ||||||||
Subject Keywords: | Central spindle, Cleavage furrow, Contractile ring, Cytokinesis, Microtubules, Rho GTPases | ||||||||
Issue or Number: | 8 | ||||||||
DOI: | 10.1242/jcs.02335 | ||||||||
Record Number: | CaltechAUTHORS:20201002-140639832 | ||||||||
Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20201002-140639832 | ||||||||
Official Citation: | Cleavage furrow formation and ingression during animal cytokinesis: a microtubule legacy Pier Paolo D'Avino, Matthew S. Savoian, David M. Glover Journal of Cell Science 2005 118: 1549-1558; doi: 10.1242/jcs.02335 | ||||||||
Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||
ID Code: | 105762 | ||||||||
Collection: | CaltechAUTHORS | ||||||||
Deposited By: | George Porter | ||||||||
Deposited On: | 05 Oct 2020 16:24 | ||||||||
Last Modified: | 16 Nov 2021 18:46 |
Repository Staff Only: item control page