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Spatiotemporal strategies to identify aggressive biology in precancerous breast biopsies

Frankhauser, David E. and Jovanovic‐Talisman, Tijana and Lai, Lily and Yee, Lisa D. and Wang, Lihong V. and Mahabal, Ashish and Geradts, Joseph and Rockne, Russell C. and Tomsic, Jerneja and Jones, Veronica and Sistrunk, Christopher and Miranda‐Carboni, Gustavo and Dietze, Eric C. and Erhunmwunsee, Loretta and Hyslop, Terry and Seewaldt, Victoria L. (2020) Spatiotemporal strategies to identify aggressive biology in precancerous breast biopsies. Wiley Interdisciplinary Reviews: Systems Biology and Medicine . ISSN 1939-005X. (In Press) https://resolver.caltech.edu/CaltechAUTHORS:20201005-104057368

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Abstract

Over 90% of breast cancer is cured; yet there remain highly aggressive breast cancers that develop rapidly and are extremely difficult to treat, much less prevent. Breast cancers that rapidly develop between breast image screening are called “interval cancers.” The efforts of our team focus on identifying multiscale integrated strategies to identify biologically aggressive precancerous breast lesions. Our goal is to identify spatiotemporal changes that occur prior to development of interval breast cancers. To accomplish this requires integration of new technology. Our team has the ability to perform single cell in situ transcriptional profiling, noncontrast biological imaging, mathematical analysis, and nanoscale evaluation of receptor organization and signaling. These technological innovations allow us to start to identify multidimensional spatial and temporal relationships that drive the transition from biologically aggressive precancer to biologically aggressive interval breast cancer.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1002/wsbm.1506DOIArticle
https://onlinelibrary.wiley.com/doi/full/10.1002/wsbm.1506PublisherArticle
ORCID:
AuthorORCID
Wang, Lihong V.0000-0001-9783-4383
Mahabal, Ashish0000-0003-2242-0244
Additional Information:© 2020 The Authors. WIREs Systems Biology and Medicine published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. Version of Record online: 01 October 2020; Manuscript accepted: 24 August 2020; Manuscript revised: 21 August 2020; Manuscript received: 29 September 2019. Funding Information: National Cancer Institute. Grant Numbers: 3U01CA189283‐S1, P20 CA24619, P30CA033572, R01CA170851, R01CA192914, R01CA220693, T32 CA221709, U01CA189283. The authors have declared no conflicts of interest for this article. Author Contributions: David Frankhauser: Conceptualization; funding acquisition; writing‐review and editing. Tijana Jovanovic‐Talisman: Conceptualization; methodology; writing‐original draft; writing‐review and editing. Lily Lai: Conceptualization; methodology; writing‐original draft; writing‐review and editing. Lisa Yee: Conceptualization; funding acquisition; writing‐review and editing. Lihong Wang: Conceptualization; methodology; writing‐original draft; writing‐review and editing. Ashish Mahabal: Conceptualization; methodology; writing‐original draft; writing‐review and editing. Joseph Geradts: Methodology; writing‐original draft; writing‐review and editing. Russell Rockne: Methodology; writing‐original draft; writing‐review and editing. Jerneja Tomsic: Conceptualization; writing‐review and editing. Veronica Jones: Funding acquisition; writing‐review and editing. Christopher Sistrunk: Funding acquisition; writing‐review and editing. Gustavo Miranda‐Carboni: Conceptualization; methodology; writing‐review and editing. Eric Dietze: Writing‐original draft; writing‐review and editing. Loretta Erhunmwunsee: Writing‐original draft; writing‐review and editing. Terry Hyslop: Conceptualization; funding acquisition; methodology; writing‐review and editing. Victoria Seewaldt: Conceptualization; funding acquisition; writing‐original draft; writing‐review and editing.
Funders:
Funding AgencyGrant Number
National Cancer InstituteUNSPECIFIED
NIH3U01CA189283‐S1
NIHP20 CA24619
NIHP30CA033572
NIHR01CA170851
NIHR01CA192914
NIHR01CA220693
NIH Predoctoral FellowshipT32 CA221709
NIHU01CA189283
Subject Keywords:breast imaging; early detection; multiscale models
Record Number:CaltechAUTHORS:20201005-104057368
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20201005-104057368
Official Citation:Frankhauser DE, Jovanovic-Talisman T, Lai L, et al. Spatiotemporal strategies to identify aggressive biology in precancerous breast biopsies. WIREs Syst Biol Med. 2020;e1506. https://doi.org/10.1002/wsbm.1506
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:105786
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:05 Oct 2020 17:55
Last Modified:05 Oct 2020 17:55

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