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Polo kinase: the choreographer of the mitotic stage?

Glover, David M. and Ohkura, Hiroyuki and Tavares, Álvaro (1996) Polo kinase: the choreographer of the mitotic stage? Journal of Cell Biology, 135 (6). pp. 1681-1684. ISSN 0021-9525. PMCID PMC2133943. doi:10.1083/jcb.135.6.1681.

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The regulation of protein function through phosphorylation is fundamental in controlling cell cycle progression. To date, most attention has focused on the cyclin-dependent protein kinases (cdks) 1 (for review see reference 21). However, whereas the p34^(cdc)-cyclin B complex appears to regulate the mitotic "state" and in this way changes the overall organization of the cell, members of another conserved serine/threonine kinase family appears to be able to control the dynamics of cellular architecture. These are the polo-like kinases (plks) which orchestrate several mitotic events including the formation of the bipolar spindle, and at least in some organisms, the process of cytokinesis. It appears that in some of its roles the plk cooperates with p34^(cdc2) and indeed recent work (15) has suggested that one plk can help maintain the mitotic state by phosphorylating the cdc25 phosphatase that activates p34^(cdc2).

Item Type:Article
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URLURL TypeDescription CentralArticle
Glover, David M.0000-0003-0956-0103
Additional Information:© The Rockefeller University Press 1996. After the Initial Publication Period, RUP will grant to the public the non-exclusive right to copy, distribute, or display the Article under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 International license, as described at, or updates thereof. Received for publication 16 October 1996 and in revised form 14 November 1996. We apologize to authors whose work we have not cited due to space constraints. Work on plks in the authors' laboratory is supported by grants from the Cancer Research Campaign, the BBSRC, and the European Union.
Funding AgencyGrant Number
Cancer Research CampaignUNSPECIFIED
Biotechnology and Biological Sciences Research Council (BBSRC)UNSPECIFIED
Issue or Number:6
PubMed Central ID:PMC2133943
Record Number:CaltechAUTHORS:20201005-153617012
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Official Citation:D M Glover, H Ohkura, A Tavares; Polo kinase: the choreographer of the mitotic stage?. J Cell Biol 15 December 1996; 135 (6): 1681–1684. doi:
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:105824
Deposited By: George Porter
Deposited On:06 Oct 2020 14:21
Last Modified:16 Nov 2021 18:46

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