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Zinc homeostasis and signaling in the roundworm C. elegans

Earley, Brian J. and Mendoza, Adelita D. and Tan, Chieh-Hsiang and Kornfeld, Kerry (2021) Zinc homeostasis and signaling in the roundworm C. elegans. Biochimica et Biophysica Acta, 1868 (1). Art. No. 118882. ISSN 0167-4889.

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C. elegans is a powerful model for studies of zinc biology. Here we review recent discoveries and emphasize the advantages of this model organism. Methods for manipulating and measuring zinc levels have been developed in or adapted to the worm. The C. elegans genome encodes highly conserved zinc transporters, and their expression and function are beginning to be characterized. Homeostatic mechanisms have evolved to respond to high and low zinc conditions. The pathway for high zinc homeostasis has been recently elucidated based on the discovery of the master regulator of high zinc homeostasis, HIZR-1. A parallel pathway for low zinc homeostasis is beginning to emerge based on the discovery of the Low Zinc Activation promoter element. Zinc has been established to play a role in two cell fate determination events, and accumulating evidence suggests zinc may function as a second messenger signaling molecule during vulval cell development and sperm activation.

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Additional Information:© 2020 Published by Elsevier B.V. Received 4 July 2020, Revised 11 September 2020, Accepted 25 September 2020, Available online 2 October 2020. The authors are grateful to the CGC, which is funded by NIH Office of Research Infrastructure Programs (P40 OD010440), for providing strains that were integral to the reviewed literature. Funding from National Institutes of Health (grant number R01 GM068598 received by KK and F31 ES030622 received by BJE) supported this review. CRediT authorship contribution statement: Brian J. Earley: Writing - original draft, Writing - review & editing, Visualization. Adelita D. Mendoza: Writing - original draft, Writing - review & editing. Chieh-Hsiang Tan: Writing - original draft, Writing - review & editing. Kerry Kornfeld: Writing - review & editing. The authors have declared that no competing interests exist.
Funding AgencyGrant Number
NIHP40 OD010440
NIHR01 GM068598
NIH Postdoctoral FellowshipF31 ES030622
Subject Keywords:HIZR-1; sperm activation; LZA; vulval development; zinc transporters; lysosome-related organelles
Issue or Number:1
Record Number:CaltechAUTHORS:20201006-130406237
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Official Citation:Brian J. Earley, Adelita D. Mendoza, Chieh-Hsiang Tan, Kerry Kornfeld, Zinc homeostasis and signaling in the roundworm C. elegans, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Volume 1868, Issue 1, 2021, 118882, ISSN 0167-4889, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:105841
Deposited By: Tony Diaz
Deposited On:07 Oct 2020 00:19
Last Modified:20 Oct 2020 17:51

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