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Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant

Earnshaw, W. C. and Allshire, R. C. and Black, B. E. and Bloom, K. and Brinkley, B. R. and Brown, W. and Cheeseman, I. M. and Choo, K. H. A. and Copenhaver, G. P. and DeLuca, J. G. and Desai, A. and Diekmann, S. and Erhardt, S. and Fitzgerald-Hayes, M. and Foltz, D. and Fukagawa, T. and Gassmann, R. and Gerlich, D. W. and Glover, D. M. and Gorbsky, G. J. and Harrison, S. C. and Heun, P. and Hirota, T. and Jansen, L. E. T. and Karpen, G. and Kops, G. J. P. L. and Lampson, M. A. and Lens, S. M. and Losada, A. and Luger, K. and Maiato, H. and Maddox, P. S. and Margolis, R. L. and Masumoto, H. and McAinsh, A. D. and Mellone, B. G. and Meraldi, P. and Musacchio, A. and Oegema, K. and O’Neill, R. J. and Salmon, E. D. and Scott, K. C. and Straight, A. F. and Stukenberg, P. T. and Sullivan, B. A. and Sullivan, K. F. and Sunkel, C. E. and Swedlow, J. R. and Walczak, C. E. and Warburton, P. E. and Westermann, S. and Willard, H. F. and Wordeman, L. and Yanagida, M. and Yen, T. J. and Yoda, K. and Cleveland, D. W. (2013) Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant. Chromosome Research, 21 (2). pp. 101-106. ISSN 0967-3849. PMCID PMC3627038. doi:10.1007/s10577-013-9347-y. https://resolver.caltech.edu/CaltechAUTHORS:20201007-123358388

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Abstract

The first centromeric protein identified in any species was CENP-A, a divergent member of the histone H3 family that was recognised by autoantibodies from patients with scleroderma-spectrum disease. It has recently been suggested to rename this protein CenH3. Here, we argue that the original name should be maintained both because it is the basis of a long established nomenclature for centromere proteins and because it avoids confusion due to the presence of canonical histone H3 at centromeres.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1007/s10577-013-9347-yDOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627038/PubMed CentralArticle
ORCID:
AuthorORCID
Glover, D. M.0000-0003-0956-0103
Additional Information:© The Author(s) 2013. This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. Received: 15 March 2013 / Revised: 17 March 2013 / Accepted: 17 March 2013 / Published online: 12 April 2013. WCE and RCA are Principal Reseach Fellows of the Wellcome Trust [grant numbers 073915 and 095021, respectively]. The Wellcome Trust Centre for Cell Biology is supported by core grant numbers 077707 and 092076. BEB is funded by NIH R01-GM082989, a Career Award in the Biomedical Sciences from the Burroughs Wellcome Fund and a Rita Allen Foundation Scholar Award. KB is funded by grant R37 GM32238. IMC is funded by NIH grant GM088313. DWC is an Investigator of the Ludwig Institute, whose centromere work is supported by NIH grant GM074150. GPC thanks the National Science Foundation (MCB-1121563) for support. JGD is supported by NIH R01GM088371. TF is supported by the Cabinet Office, Government of Japan, through its ‘Funding Program for Next Generation World-Leading Researchers’(LS122). RG is funded by an EMBO Installation Grant. DWG is funded by the European Community’s Seventh Framework Programme FP7/2007-2013 under grant agreements no. 241548 (MitoSys) and no. 258068 (Systems Microscopy) and from an ERC Starting Grant (no. 281198). DMG is supported by Cancer Research UK and the MRC. GJG is funded by NIH/NIGMS R01-50412, the Oklahoma Center for Advancement of Science and Technology and the McCasland Foundation. PH is funded by Seventh Framework Programme grant BioSynCen from the European Research Council. TH is funded by Research Grants from the Japanese Society for the Promotion of Science (JSPS) and the Ministry of Education, Culture, Sports, Science and Technology in Japan (MEXT). LETJ is funded by FCT grants BIA-BCM/100557/2008, BIAPRO/100537/2008 and an EMBO installation grant. GK is funded by NIH grant 5R01GM61169, GJPLK is supported by grants from the ERC (KINSIGN) and the Netherlands Organisation for Scientific Research (NWO-Vici-016.130.661). MAL is funded by NIH grant GM083988. SML is supported by grants from the Dutch Cancer Society (UU2009-4311, UU2011-5134) and the Netherlands Organisation for Scientific Research (NWO-Vici-91812610). AL is supported by the Spanish Ministry of Economy (grants CSD2007-015 and SAF2010-25157) and the EU (Marie Curie ITN “Nucleosome 4D”). HM is funded by grants PTDC/SAU-GMG/099704/2008 and PTDC/SAU-ONC/112917/2009 from FCT (COMPETE-FEDER), the Human Frontier Science Program and the 7th framework program grant PRECISE from the European Research Council. ADM is funded by BBSRC grant (BB/I021353/1). RLM is funded by NIH grant R01GM088716. HM is supported in part by Grants-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan, and the Kazusa DNA Research Institute Foundation. PSM is supported by a grant from the CCSRI (700824). BGM is funded by NSF award number 1024973. PM is funded by the Swiss National Foundation, University of Geneva and the Foundation Louis-Jeantet. RJO is supported by the NSF. EDS is funded by NIH grant R37GM024364. AFS is funded by NIH grant R01GM074728. PTS is funded by NIH grant number-R01 GM063045. BS is funded by NIH R01 GM098500 and March of Dimes 6-FY10-294. KFS is funded by Science Foundation Ireland grant 12/IA/1370. CES is funded by grants from the Fundação para Ciência e Tecnologia of Portugal, COMPETE and ON2. JRS is funded by BBSRC grant BB/H013024. CEW is funded by NIH grant GM059618. LW is funded by NIH grant GM69429. TY is funded by NIH grant GM083988, Core Grant CA06927, and an appropriation from the Commonwealth of Pennsylvania.
Funders:
Funding AgencyGrant Number
Wellcome Trust073915
Wellcome Trust095021
Wellcome Trust077707
Wellcome Trust092076
NIHR01-GM082989
Burroughs Wellcome FundUNSPECIFIED
Rita Allen FoundationUNSPECIFIED
NIHR37 GM32238
NIHGM088313
Ludwig InstituteUNSPECIFIED
NIHGM074150
NSFMCB-1121563
NIHR01GM088371
Cabinet Office, Government of JapanLS122
European Molecular Biology Organization (EMBO)UNSPECIFIED
European Research Council (ERC)241548
European Research Council (ERC)258068
European Research Council (ERC)281198
Cancer Research UKUNSPECIFIED
Medical Research Council (UK)UNSPECIFIED
NIHR01-50412
Oklahoma Center for Advancement of Science and TechnologyUNSPECIFIED
McCasland FoundationUNSPECIFIED
Japan Society for the Promotion of Science (JSPS)UNSPECIFIED
Ministry of Education, Culture, Sports, Science and Technology (MEXT)UNSPECIFIED
Fundação para a Ciência e a Tecnologia (FCT)BIA-BCM/100557/2008
Fundação para a Ciência e a Tecnologia (FCT)BIAPRO/100537/2008
NIH5R01GM61169
Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO)NWO-Vici-016.130.661
NIHGM083988
Dutch Cancer SocietyUU2009-4311
Dutch Cancer SocietyUU2011-5134
Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO)NWO-Vici-91812610
Ministerio de Economía, Industria y Competitividad (MINECO)CSD2007-015
Ministerio de Economía, Industria y Competitividad (MINECO)SAF2010-25157
Marie Curie FellowshipUNSPECIFIED
Fundação para a Ciência e a Tecnologia (FCT)PTDC/SAU-GMG/099704/2008
Fundação para a Ciência e a Tecnologia (FCT)PTDC/SAU-ONC/112917/2009
Fondo Europeo de Desarrollo Regional (FEDER)UNSPECIFIED
Human Frontier Science ProgramUNSPECIFIED
Biotechnology and Biological Sciences Research Council (BBSRC)BB/I021353/1
NIHR01GM088716
Kazusa DNA Research Institute FoundationUNSPECIFIED
Canadian Cancer Society Research Institute700824
NSFMCB-1024973
Swiss National Science Foundation (SNSF)UNSPECIFIED
University of GenevaUNSPECIFIED
Foundation Louis-JeantetUNSPECIFIED
NIHR37GM024364
NIHR01GM074728
NIHR01 GM063045
NIHR01 GM098500
March of Dimes6-FY10-294
Science Foundation, Ireland12/IA/1370
Biotechnology and Biological Sciences Research Council (BBSRC)BB/H013024
NIHGM059618
NIHGM69429
NIHGM083988
NIHCA06927
Commonwealth of PennsylvaniaUNSPECIFIED
Fundação para a Ciência e a Tecnologia (FCT)COMPETE
Fundação para a Ciência e a Tecnologia (FCT)ON2
Issue or Number:2
PubMed Central ID:PMC3627038
DOI:10.1007/s10577-013-9347-y
Record Number:CaltechAUTHORS:20201007-123358388
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20201007-123358388
Official Citation:Earnshaw, W.C., Allshire, R.C., Black, B.E. et al. Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant. Chromosome Res 21, 101–106 (2013). https://doi.org/10.1007/s10577-013-9347-y
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:105878
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:08 Oct 2020 14:07
Last Modified:16 Nov 2021 18:47

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