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Characterization of voltage-gated calcium channels in Xenopus oocytes after injection of RNA from electrically excitable tissues

Snutch, Terry P. and Leonard, John P. and Nargeot, Joël and Lübbert, Hermann and Davidson, Norman and Lester, Henry A. (1987) Characterization of voltage-gated calcium channels in Xenopus oocytes after injection of RNA from electrically excitable tissues. Society of General Physiologists series, 42 . pp. 153-166. ISSN 0094-7733.

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The entry of Ca²⁺ through voltage-gated channels has two major functions. First, Ca²⁺ fluxes elevate the intracellular concentration of this important second messenger. Second, Ca²⁺ currents directly influence membrane potential, thereby contributing to impulse patterns. Ca²⁺ channels serve these functions in a variety of nerve, muscle, and endocrine cells (Reuter, 1983; Tsien, 1983). As might be expected from their wide distribution and their role in regulating a number of cellular functions, voltage-gated Ca²⁺ channels form a heterogeneous family. Diverse types of Ca²⁺ channels can be distinguished with regard to gating kinetics, pharmacology, and permeability (Fox and Krasne, 1981; Armstrong and Matteson, 1985; Nowyeky et al., 1985). For the purpose of characterizing the various forms of voltage-gated Ca²⁺ channels, it would be desirable to study them in a similar membrane environment.

Item Type:Article
Lester, Henry A.0000-0002-5470-5255
Additional Information:© 1987 Raven Press. We thank Dr. Douglas Krafte and Dr. Nathan Dascal for their comments on this manuscript. We also thank Moira Fearey for excellent technical assistance. This research was supported by fellowships from the American Heart Association Greater Los Angeles Affiliate, and the Natural Science and Engineering Research Council of Canada, and by grants GM-10991, GM-29836, and HL-35782 from the National Institutes of Health. J.N. thanks Laboratoire Servier (Neuilly-sur-Seine) for a travel grant.
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American Heart AssociationUNSPECIFIED
Natural Sciences and Engineering Research Council of Canada (NSERC)UNSPECIFIED
Laboratoires ServierUNSPECIFIED
Record Number:CaltechAUTHORS:20201009-153923021
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ID Code:105976
Deposited By: George Porter
Deposited On:09 Oct 2020 22:45
Last Modified:09 Oct 2020 23:12

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