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Software for electrophysiological experiments with a personal computer

Kegel, Daniel R. and Wolf, Benjamin D. and Sheridan, Robert E. and Lester, Henry A. (1985) Software for electrophysiological experiments with a personal computer. Journal of Neuroscience Methods, 12 (4). pp. 317-330. ISSN 0165-0270. doi:10.1016/0165-0270(85)90016-0. https://resolver.caltech.edu/CaltechAUTHORS:20201012-152226500

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Abstract

These programs were written for the IBM personal computer equipped with a Tecmar Labmaster analog interface board. The software operates under the MS-DOS operating system; it is written in compiled BASIC and employs short machine-language subroutines for crucial functions. Details are presented on the analog interface routines which make special use of the 9513 counter/timer chip on the Labmaster. Time resolution is about 32 μs per sample on the PC and 15 μs on the PC/AT. One series of programs performs traditional voltage- and current-clamp experiments on macroscopic currents in whole cells. A second series interfaces with a hardware window discriminator to capture single-channel events in a recirculating buffer, a stimulus can be triggered to fire during an open channel. Off-line programs perform standard analyses, and further processing can be performed with standard spreadsheet programs.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/0165-0270(85)90016-0DOIArticle
ORCID:
AuthorORCID
Lester, Henry A.0000-0002-5470-5255
Additional Information:© 1985 Published by Elsevier. Received 17 October 1984, Revised 22 November 1984, Accepted 23 November 1984. We thank Mr. Michael Walsh in Caltech's Biology Electronics Shop for designing and building the window discriminator and the timeshare circuit. We thank Alison M. Gurney, Jeanne M. Nerbonne, Lee D. Chabala, Alan Finkel, Michael M. White, and Jerome Pine for testing and advising on the system. This research was sponsored by the National Institutes of Health (NS-11756).
Funders:
Funding AgencyGrant Number
NIHNS-11756
Subject Keywords:voltage-clamp; single channels; BASIC; IBM personal computer
Issue or Number:4
DOI:10.1016/0165-0270(85)90016-0
Record Number:CaltechAUTHORS:20201012-152226500
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20201012-152226500
Official Citation:Daniel R. Kegel, Benjamin D. Wolf, Robert E. Sheridan, Henry A. Lester, Software for electrophysiological experiments with a personal computer, Journal of Neuroscience Methods, Volume 12, Issue 4, 1985, Pages 317-330, ISSN 0165-0270, https://doi.org/10.1016/0165-0270(85)90016-0.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:105997
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:12 Oct 2020 22:35
Last Modified:16 Nov 2021 18:48

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