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Expression of mRNA Encoding Voltage-Dependent Ca Channels in Xenopus Oocytes: Review and Progress Report

Lester, Henry A. and Snutch, Terry P. and Leonard, John P. and Nargeot, Joel and Dascal, Nathan and Curtis, Benson M. and Davidson, Norman (1989) Expression of mRNA Encoding Voltage-Dependent Ca Channels in Xenopus Oocytes: Review and Progress Report. Annals of the New York Academy of Sciences, 560 . pp. 174-182. ISSN 0077-8923. doi:10.1111/j.1749-6632.1989.tb24094.x.

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We are studying electrically excitable Ca channels with an approach that combines nucleic acid molecular biology and membrane biophysics. Gurdon et al. first employed Xenopus oocytes as a system for heterologous expression of RNA. This system was later adapted for electrophysiological studies of ion channels by Barnard, Miledi, and their colleagues. Although other expression systems are being developed for membrane channels [Claudio et al. and Beam et al., this volume], the oocyte is now the most common, robust, and best-characterized system. Experiments in which channels are expressed by RNA injections in oocytes have at least three major goals.

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Lester, Henry A.0000-0002-5470-5255
Additional Information:© 1989 New York Academy of Sciences. This research was sponsored by grants from the National Institutes of Health (GM‐10991 and GM‐29836), from the United States—Israel Binational Science Foundation, from the CNRS (LP 8402), and from INSERM (U249), by postdoctoral fellowships from the American Heart Association to T. S. and J. P. L., from the NIH to B. M. C., and by a Bantrell Fellowship to N. D. J. N. thanks Laboratoire Servier for a travel grant.
Funding AgencyGrant Number
Binational Science Foundation (USA-Israel)UNSPECIFIED
Centre National de la Recherche Scientifique (CNRS)LP 8402
Institut national de la santé et de la recherche médicale (INSERM)U249
American Heart AssociationUNSPECIFIED
Natural Sciences and Engineering Research Council of Canada (NSERC)UNSPECIFIED
Laboratoire ServierUNSPECIFIED
Record Number:CaltechAUTHORS:20201012-160322461
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Official Citation:LESTER, H.A., SNUTCH, T.P., LEONARD, J.P., NARGEOT, J., DASCAL, N., CURTIS, B.M. and DAVIDSON, N. (1989), Expression of mRNA Encoding Voltage‐Dependent Ca Channels in Xenopus Oocytes:. Annals of the New York Academy of Sciences, 560: 174-182. doi:10.1111/j.1749-6632.1989.tb24094.x
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:106003
Deposited By: George Porter
Deposited On:13 Oct 2020 14:20
Last Modified:16 Nov 2021 18:49

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