Sutton, Fedora and Davidson, Norman and Lester, Henry A. (1988) Tetrodotoxin-sensitive voltage-dependent Na currents recorded from Xenopus oocytes injected with mammalian cardiac muscle RNA. Molecular Brain Research, 3 (2). pp. 187-191. ISSN 0169-328X. https://resolver.caltech.edu/CaltechAUTHORS:20201013-140644398
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Abstract
Voltage-sensitive sodium (Na) channel currents recorded from mammalian cardiac muscle are blocked by tetrodotoxin (TTX) with a K_d of 1–3 μM. We have observed a K_d for TTX of 4–10 nM for Na currents recorded from Xenopus oocytes injected with RNA extracted from rabbit cardiac muscle. This result suggests that the degree of TTX sensitivity of Na channels encoded by cardiac muscle mRNA is in part determined by post-translational modification(s) or of associations with accessory proteins in the membrane.
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| Additional Information: | © 1988 Published by Elsevier. Accepted 22 September 1987. We thank David J. Anderson for the gift of the neuronal specific clone SCG10; Kiyonori Yoshii for his assistance and advice with the initial electrophysiological experiments; Douglas Krafte for generous help and advice. This work was supported by NIH Grant HL 35782 and fellowships from the California Institute of Technology and the NIH to F.S. | ||||||||
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| Subject Keywords: | Xenopus oocyte; Tetrodotoxin; Cardiac; Ribonucleic acid | ||||||||
| Issue or Number: | 2 | ||||||||
| Record Number: | CaltechAUTHORS:20201013-140644398 | ||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20201013-140644398 | ||||||||
| Official Citation: | Fedora Sutton, Norman Davidson, Henry A. Lester, Tetrodotoxin-sensitive voltage-dependent Na currents recorded from Xenopus oocytes injected with mammalian cardiac muscle RNA, Molecular Brain Research, Volume 3, Issue 2, 1988, Pages 187-191, ISSN 0169-328X, https://doi.org/10.1016/0169-328X(88)90065-4. | ||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||
| ID Code: | 106037 | ||||||||
| Collection: | CaltechAUTHORS | ||||||||
| Deposited By: | George Porter | ||||||||
| Deposited On: | 13 Oct 2020 22:16 | ||||||||
| Last Modified: | 13 Oct 2020 22:16 |
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