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Light-flash physiology with synthetic photosensitive compounds

Gurney, Alison M. and Lester, Henry A. (1987) Light-flash physiology with synthetic photosensitive compounds. Physiological Reviews, 67 (2). pp. 583-617. ISSN 0031-9333. doi:10.1152/physrev.1987.67.2.583.

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This review treats a technique that has proved useful recently in some physiological studies. A process is measured while a light flash is used to manipulate a physiologically important or pharmacologically active photosensitive molecule. Typically such experiments complement more common measurements of 1) equilibrium responses in the same system or 2) relaxations after voltage jumps, rapid mixing, and so on. The chief advantage of the lightflash technique is the speed of the photochemistry and the fact that it can be applied to organized systems, such as muscle fibers and membranes under electrophysiological investigation, that cannot be flowed. Experiments may be classified by the accessible time scales (Table 1), by successful recording techniques (Table 2), and by available molecules (Table 3).

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Lester, Henry A.0000-0002-5470-5255
Additional Information:© 1987 American Physiological Society. We thank A. Cuthbert, J. M. Nerbonne, D. Trentham, R. Y. Tsien, and our many other colleagues and collaborators over the past 10 years for advice, encouragement, and ideas. The research at California Institute of Technology has been supported by grants from the National Institutes of Health (NS-11756 and GM-29836) and by fellowships and grants from the American Heart Association and the Muscular Dystrophy Association. The literature search for this review was completed in July 1986.
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American Heart AssociationUNSPECIFIED
Muscular Dystrophy AssociationUNSPECIFIED
Issue or Number:2
Record Number:CaltechAUTHORS:20201013-140644623
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Official Citation:Light-flash physiology with synthetic photosensitive compounds. A M Gurney and H A Lester Physiological Reviews 1987 67:2, 583-617
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:106039
Deposited By: George Porter
Deposited On:13 Oct 2020 21:19
Last Modified:16 Nov 2021 18:49

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