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Engineering the Composition and Fate of Wild Populations with Gene Drive

Hay, Bruce A. and Oberhofer, Georg and Guo, Ming (2020) Engineering the Composition and Fate of Wild Populations with Gene Drive. Annual Review of Entomology . ISSN 0066-4170. (In Press) https://resolver.caltech.edu/CaltechAUTHORS:20201019-075224449

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Abstract

Insects play important roles as predators, prey, pollinators, recyclers, hosts, parasitoids, and sources of economically important products. They can also destroy crops; wound animals; and serve as vectors for plant, animal, and human diseases. Gene drive—a process by which genes, gene complexes, or chromosomes encoding specific traits are made to spread through wild populations, even if these traits result in a fitness cost to carriers—provides new opportunities for altering populations to benefit humanity and the environment in ways that are species specific and sustainable. Gene drive can be used to alter the genetic composition of an existing population, referred to as population modification or replacement, or to bring about population suppression or elimination. We describe technologies under consideration, progress that has been made, and remaining technological hurdles, particularly with respect to evolutionary stability and our ability to control the spread and ultimate fate of genes introduced into populations.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1146/annurev-ento-020117-043154DOIArticle
ORCID:
AuthorORCID
Hay, Bruce A.0000-0002-5486-0482
Oberhofer, Georg0000-0003-0930-1996
Additional Information:© 2020 Annual Reviews. Review in Advance first posted online on October 9, 2020.
Record Number:CaltechAUTHORS:20201019-075224449
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20201019-075224449
Official Citation:Engineering the Composition and Fate of Wild Populations with Gene Drive. Bruce A. Hay, Georg Oberhofer, Ming Guo. Annual Review of Entomology 2021 66:1; doi: 10.1146/annurev-ento-020117-043154
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:106132
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:20 Oct 2020 15:50
Last Modified:20 Oct 2020 15:50

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