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Translational Approaches to Electrical Stimulation for Peripheral Nerve Regeneration

Ransom, Seth C. and Shahrestani, Shane and Lien, Brian V. and Tafreshi, Ali R. and Brown, Nolan J. and Hanst, Brian and Lehrich, Brandon M. and Ransom, R. Chase and Sahyouni, Ronald (2020) Translational Approaches to Electrical Stimulation for Peripheral Nerve Regeneration. Neurorehabilitation and Neural Repair, 34 (11). pp. 979-985. ISSN 1545-9683.

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Background: Achieving functional repair after peripheral nerve injury (PNI) remains problematic despite considerable advances in surgical technique. Therein, questions lie regarding the variable capacity of peripheral nerves to regenerate based on environmental influence. In-depth analyses of multiple therapeutic strategies have ensued to overcome these natural obstacles. Of these candidate therapies, electrical stimulation has emerged a frontrunner. Extensive animal studies have reported the ability of brief intraoperative electrical stimulation (BES) to enhance functional regeneration after PNI. Despite these reports, the exact mechanisms by which BES enhances regeneration and its effects on long nerve lesions are largely unknown. Indeed, clinical translation of this seemingly simple therapeutic has not been so simple, but a few studies performed in humans have yielded highly encouraging results. Objective: We aimed to help bridge this translational gap by presenting the latest clinical trials on electrical stimulation for PNIs in combination with relevant etiologies, treatments and nonclinical findings. Methods: To do so, a systematic search was performed on PubMed, IEEE, and Web of Science databases up to February 2020 using keywords significant to our study. References of each manuscript were screened for additional manuscripts of relevance to our study. Results: We found multiple BES clinical studies reporting enhanced functional recovery or increased nerve regeneration. Although improved outcomes were reported, high variability after BES is seen between and within species likely due to injury severity, location and timeline along with other factors. Conclusion: Further clinical studies and introduction of novel delivery platforms are vital to uncover the true regenerative potential of electrical stimulation therapy.

Item Type:Article
Related URLs:
URLURL TypeDescription
Ransom, Seth C.0000-0001-5949-1703
Shahrestani, Shane0000-0001-7561-4590
Lien, Brian V.0000-0003-3044-8626
Tafreshi, Ali R.0000-0002-8956-3373
Brown, Nolan J.0000-0002-6025-346X
Hanst, Brian0000-0002-0433-2542
Lehrich, Brandon M.0000-0003-1003-5605
Ransom, R. Chase0000-0001-6696-1793
Sahyouni, Ronald0000-0002-2124-0535
Additional Information:© 2020 SAGE Publications. Article first published online: October 10, 2020; Issue published: November 1, 2020.
Funding AgencyGrant Number
NIH Predoctoral FellowshipT32-GM08620
Subject Keywords:electrical stimulation, regeneration, peripheral nerve injury, therapy
Issue or Number:11
Record Number:CaltechAUTHORS:20201019-122947635
Persistent URL:
Official Citation:Ransom SC, Shahrestani S, Lien BV, et al. Translational Approaches to Electrical Stimulation for Peripheral Nerve Regeneration. Neurorehabilitation and Neural Repair. 2020; 34(11):979-985. doi:10.1177/1545968320962508
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:106148
Deposited By: Tony Diaz
Deposited On:20 Oct 2020 18:13
Last Modified:11 Nov 2020 20:30

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