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Molecular and genetic approaches to the analysis of the informational content of the mitochondrial genome in mammalian cells

Attardi, Giuseppe and Costantino, Paolo and Lynch, Dennis and Mitchell, Carolyn and Murphy, William and Ojala, Deanna (1977) Molecular and genetic approaches to the analysis of the informational content of the mitochondrial genome in mammalian cells. Molecular and Cellular Biochemistry, 14 (1-3). pp. 151-164. ISSN 0300-8177. https://resolver.caltech.edu/CaltechAUTHORS:20201020-071345556

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Abstract

Our laboratory has been involved in the last few years in investigations aiming at analyzing by molecular approaches the informational content of the mitochondrial genome in mammalian cells and the mechanisms and control of its expression. HeLa cells and other mammalian cell lines have been utilized for these studies. These investigations, as well as work carried out in other laboratories, have yielded a considerable amount of information concerning the mechanism, products and regulation of transcription of mitochondrial DNA (mit-DNA), the apparatus and products of mitochondria-specific protein synthesis in animal cells, and the number and topology of the sites on mit-DNA which code for the primary gene products identified so far. It is the purpose of the present report to summarize the latest observations in this area, as well as some recent results on the isolation and characterization of chloramphenicol-resistant variants of a human cell line. Reference is made to previous review articles for the earlier work.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1007/bf01734179DOIArticle
Additional Information:© 1977 Springer-Verlag.
Subject Keywords:Protein Synthesis; Mammalian Cell; HeLa Cell; Human Cell; Recent Result
Issue or Number:1-3
Record Number:CaltechAUTHORS:20201020-071345556
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20201020-071345556
Official Citation:Attardi, G., Costantino, P., Lynch, D. et al. Molecular and genetic approaches to the analysis of the informational content of the mitochondrial genome in mammalian cells. Mol Cell Biochem 14, 151–164 (1977). https://doi.org/10.1007/BF01734179
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:106154
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:20 Oct 2020 19:15
Last Modified:20 Oct 2020 19:15

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