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Distinct roles of dorsal and ventral subthalamic neurons in action selection and cancellation

Mosher, Clayton P. and Mamelak, Adam N. and Malekmohammadi, Mahsa and Pouratian, Nader and Rutishauser, Ueli (2020) Distinct roles of dorsal and ventral subthalamic neurons in action selection and cancellation. . (Unpublished) https://resolver.caltech.edu/CaltechAUTHORS:20201021-081440207

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Abstract

The subthalamic nucleus (STN) supports action selection by inhibiting all motor programs except the desired one. Recent evidence suggests that STN can also cancel an already selected action when goals change, a key aspect of cognitive control. However, there is little neurophysiological evidence for a dissociation between selecting and cancelling actions in the human STN. We recorded single neurons in the STN of humans performing a stop-signal task. Movement-related neurons suppressed their activity during successful stopping whereas stop-signal neurons activated at low-latencies regardless of behavioral outcome. In contrast, STN and motor-cortical beta-bursting occurred only later in the stopping process. Task-related neuronal properties varied by recording location from dorsolateral movement to ventromedial stop-signal tuning. Therefore, action selection and cancellation coexist in STN but are anatomically segregated. These results show that human ventromedial STN neurons carry fast stop-related signals suitable for implementing cognitive control.


Item Type:Report or Paper (Discussion Paper)
Related URLs:
URLURL TypeDescription
https://doi.org/10.1101/2020.10.16.342980DOIDiscussion Paper
ORCID:
AuthorORCID
Mamelak, Adam N.0000-0002-4245-6431
Pouratian, Nader0000-0002-0426-3241
Rutishauser, Ueli0000-0002-9207-7069
Additional Information:The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. Posted October 17, 2020. We gratefully acknowledge the willingness of our patients to participate in this study. We thank Dr. Michele Tagliati for patient referrals, the staff and physicians of the Movement Disorders Program at Cedars-Sinai Medical Center for support; Robert Zelaya, Lori Scheinost, Andy Nguyen, and Cody Holland for assistance with intraoperative recordings; Jan Kaminksi, Jeong Woo Choi, and Steven Errington for discussion and feedback on the manuscript; Adam Aron for advice and for contributing to writing the grant that partially funded this work. This work was supported by the BRAIN initiative through grants from the National Institute of Neurological Disorders and Stroke (U01NS103792 to UR, U01NS098961 to NP and UR). Author Contributions: M.M., N.P., and U.R. designed experiments. N.P. and U.R acquired funding and supervised the project. M.M. wrote initial experimental code and organized early phases of the project. A.N.M performed surgery. A.N.M. and C.P.M. performed experiments and recorded the data. C.P.M. analyzed the data and wrote the initial draft of the manuscript. All authors discussed the results at all stages of the project and contributed to the final manuscript. The authors declare no competing interests.
Funders:
Funding AgencyGrant Number
NIHU01NS103792
NIHU01NS098961
Record Number:CaltechAUTHORS:20201021-081440207
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20201021-081440207
Official Citation:Distinct roles of dorsal and ventral subthalamic neurons in action selection and cancellation. Clayton P. Mosher, Adam N. Mamelak, Mahsa Malekmohammadi, Nader Pouratian, Ueli Rutishauser. bioRxiv 2020.10.16.342980; doi: https://doi.org/10.1101/2020.10.16.342980
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:106179
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:21 Oct 2020 16:37
Last Modified:21 Oct 2020 16:37

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