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Proteins for increased surface expression of the α6β4 nicotinic acetylcholine receptor: Nothing but good news?

Grant, Stephen and Lester, Henry A. (2020) Proteins for increased surface expression of the α6β4 nicotinic acetylcholine receptor: Nothing but good news? Journal of Clinical Investigation, 130 (11). pp. 5685-5687. ISSN 0021-9738. PMCID PMC7598034. doi:10.1172/jci143197. https://resolver.caltech.edu/CaltechAUTHORS:20201028-074338126

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Abstract

Useful animal models of disease in neuroscience can make accurate predictions about a therapeutic outcome, a feature known as predictive validity. In this issue of the JCI, Knowland et al. provide an improved model to assess nicotinic acetylcholine receptor (nAChR) ligands for treating chronic pain. The authors identify two proteins, the voltage-dependent calcium channel auxiliary subunit BARP and the unfolded protein response sensor IRE1α, that are required for robust heterologous expression of α6β4, an nAChR subtype in dorsal root ganglia (DRG). This nAChR is a candidate for the analgesic effects of nicotine as well as the frog toxin epibatidine. Now researchers can efficiently screen for α6β4 nAChR–selective agonists using heterologous expression systems. Candidates that emerge will enable researchers to test the predictive validity of mouse models for chronic pain in the nAChR context. If all these steps work, one can envision a class of non-opioid nAChR-targeted analgesics for chronic pain.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1172/jci143197DOIArticle
ORCID:
AuthorORCID
Grant, Stephen0000-0003-0923-8886
Lester, Henry A.0000-0002-5470-5255
Additional Information:© 2020 American Society for Clinical Investigation. Published October 19, 2020.
Issue or Number:11
PubMed Central ID:PMC7598034
DOI:10.1172/jci143197
Record Number:CaltechAUTHORS:20201028-074338126
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20201028-074338126
Official Citation:Proteins for increased surface expression of the α6β4 nicotinic acetylcholine receptor: Nothing but good news? J Clin Invest. 2020; 130(11): 5685–5687. https://doi.org/10.1172/JCI143197
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:106314
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:29 Oct 2020 19:30
Last Modified:16 Nov 2021 18:52

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