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Persistent fluid flows defined by active matter boundaries

Qu, Zijie and Schildknecht, Dominik and Shadkhoo, Shahriar and Amaya, Enrique and Jiang, Jialong and Lee, Heun Jin and Phillips, Rob and Thomson, Matt (2020) Persistent fluid flows defined by active matter boundaries. . (Unpublished)

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Biological systems achieve precise control over ambient fluids through the self-organization of active protein structures including flagella, cilia, and cytoskeletal networks. In active structures individual proteins consume chemical energy to generate force and motion at molecular length scales. Self-organization of protein components enables the control and modulation of fluid flow fields on micron scales. The physical principles underlying the organization and control of active-matter driven fluid flows are poorly understood. Here, we apply an optically-controlled active-matter system composed of microtubule filaments and light-switchable kinesin motor proteins to analyze the emergence of persistent flow fields in a model active matter system. Using light, we form contractile microtubule networks of varying shape. We analyze the fluid flow fields generated by a wide range of microtubule network geometries and explain the resulting flow fields within a unified theoretical framework. We specifically demonstrate that the geometry of microtubule flux at the boundary of contracting microtubule networks predicts the steady-state fluid flow fields across polygonal network geometries through finite-element simulations. Our work provides a foundation for programming microscopic fluid-flows with controllable active matter and could enable the engineering of versatile and dynamic microfluidic devices.

Item Type:Report or Paper (Discussion Paper)
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URLURL TypeDescription Paper
Phillips, Rob0000-0003-3082-2809
Additional Information:We acknowledge funding from the Donna and Benjamin M. Rosen Bioengineering Center, Foundational Questions Institute and Fetzer Franklin Fund through FQXi 1816 , Packard foundation, and Heritage Medical Research institute. Inna-Marie Strazhnik for preparation of figures and illustrations.
Group:Rosen Bioengineering Center, Heritage Medical Research Institute
Funding AgencyGrant Number
Donna and Benjamin M. Rosen Bioengineering CenterUNSPECIFIED
Foundational Questions Institute (FQXI)FQXi 1816
Fetzer Franklin FundUNSPECIFIED
David and Lucile Packard FoundationUNSPECIFIED
Heritage Medical Research InstituteUNSPECIFIED
Record Number:CaltechAUTHORS:20201110-143708446
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:106594
Deposited By: George Porter
Deposited On:10 Nov 2020 23:11
Last Modified:10 Nov 2020 23:11

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