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Recent Advances in Homogeneous Catalysts for the Asymmetric Hydrogenation of Heteroarenes

Kim, Alexia N. and Stoltz, Brian M. (2020) Recent Advances in Homogeneous Catalysts for the Asymmetric Hydrogenation of Heteroarenes. ACS Catalysis, 10 (23). pp. 13834-13851. ISSN 2155-5435. https://resolver.caltech.edu/CaltechAUTHORS:20201112-103611899

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Abstract

The asymmetric hydrogenation of heteroarenes has recently emerged as an effective strategy for the direct access to enantioenriched, saturated heterocycles. Although several homogeneous catalyst systems have been extensively developed for the hydrogenation of heteroarenes with high levels of chemo- and stereoselectivity, the development of mild conditions that allow for efficient and stereoselective hydrogenation of a broad range of substrates remains a challenge. This Perspective highlights recent advances in homogeneous catalysis of heteroarene hydrogenation as inspiration for the further development of asymmetric hydrogenation catalysts, and addresses underdeveloped areas and limitations of the current technology.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1021/acscatal.0c03958DOIArticle
ORCID:
AuthorORCID
Kim, Alexia N.0000-0002-4060-8892
Stoltz, Brian M.0000-0001-9837-1528
Additional Information:© 2020 American Chemical Society. Received: September 9, 2020; Revised: October 15, 2020; Published: November 12, 2020. We thank NIH-NIGMS (R01GM127972A) and Caltech for funding and the support of our research program. The authors declare no competing financial interest.
Funders:
Funding AgencyGrant Number
NIHR01GM127972A
CaltechUNSPECIFIED
Subject Keywords:hydrogenation, asymmetric catalysis, heterocycles, heteroarenes, homogeneous catalysts
Issue or Number:23
Record Number:CaltechAUTHORS:20201112-103611899
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20201112-103611899
Official Citation:Recent Advances in Homogeneous Catalysts for the Asymmetric Hydrogenation of Heteroarenes. Alexia N. Kim and Brian M. Stoltz. ACS Catalysis 2020 10 (23), 13834-13851; DOI: 10.1021/acscatal.0c03958
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:106642
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:16 Nov 2020 16:02
Last Modified:09 Dec 2020 23:17

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