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The connections of the insular VEN area in great apes: A histologically-guided ex vivo diffusion tractography study

Cabeen, Ryan P. and Glass, Laura and Erwin, Joseph M. and Hof, Patrick R. and Toga, Arthur W. and Allman, John M. (2020) The connections of the insular VEN area in great apes: A histologically-guided ex vivo diffusion tractography study. Progress in Neurobiology, 195 . Art. No. 101941. ISSN 0301-0082. PMCID PMC7806049. https://resolver.caltech.edu/CaltechAUTHORS:20201117-084436182

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Abstract

We mapped the connections of the insular von Economo neuron (VEN) area in ex vivo brains of a bonobo, an orangutan and two gorillas with high angular resolution diffusion MRI imaging acquired in 36 h imaging sessions for each brain. The apes died of natural causes without neurological disorders. The localization of the insular VEN area was based on cresyl violet-stained histological sections from each brain that were coregistered with structural and diffusion images from the same individuals. Diffusion MRI tractography showed that the insular VEN area is connected with olfactory, gustatory, visual and other sensory systems, as well as systems for the mediation of appetite, reward, aversion and motivation. The insular VEN area in apes is most strongly connected with frontopolar cortex, which could support their capacity to choose voluntarily among alternative courses of action particularly in exploring for food resources. The frontopolar cortex may also support their capacity to take note of potential resources for harvesting in the future (prospective memory). All of these faculties may support insight and volitional choice when contemplating courses of action as opposed to rule-based decision-making.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/j.pneurobio.2020.101941DOIArticle
ORCID:
AuthorORCID
Cabeen, Ryan P.0000-0002-1372-3588
Hof, Patrick R.0000-0002-3208-1154
Toga, Arthur W.0000-0001-7902-3755
Additional Information:© 2020 Elsevier Ltd. Received 31 January 2020, Revised 20 October 2020, Accepted 31 October 2020, Available online 4 November 2020. We thank Michael Tyszka and Jason Kaufman for their help in acquiring the structural and diffusion MRI data used in this study. We thank Virginie Goubert for the histological processing of the brain tissue. We thank Laura Korobkova for her skillful acquisition and assembly of the photomontage in Figs. 1 and 5. Several of the ape brains involved in this study are on loan to the “Great Ape Aging Project" from zoological gardens that are accredited by the Association of Zoos and Aquariums (AZA) and that participate in the Ape Taxon Advisory Group (Ape-TAG). We especially appreciate the contribution of zoo veterinarians and staff in collecting and providing specimens. Some comparative specimens were collected under the “Comparative Neurobiology of Aging Resource," NIH/NIA grant AG014308, J. Erwin, PI. This research was supported by the James S. McDonnell Foundation, the Tianqiao and Chrissy Chen Foundation and National Institutes of Health grant number P41 EB015922.
Group:Tianqiao and Chrissy Chen Institute for Neuroscience
Funders:
Funding AgencyGrant Number
NIHAG014308
James S. McDonnell FoundationUNSPECIFIED
Tianqiao and Chrissy Chen Institute for NeuroscienceUNSPECIFIED
NIHP41 EB015922
Subject Keywords:Insula; VEN; Connection; Frontopolar; Cortex; Exploration
PubMed Central ID:PMC7806049
Record Number:CaltechAUTHORS:20201117-084436182
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20201117-084436182
Official Citation:Ryan P. Cabeen, Laura Glass, Joseph M. Erwin, Patrick R. Hof, Arthur W. Toga, John M. Allman, The connections of the insular VEN area in great apes: A histologically-guided ex vivo diffusion tractography study, Progress in Neurobiology, Volume 195, 2020, 101941, ISSN 0301-0082, https://doi.org/10.1016/j.pneurobio.2020.101941. (http://www.sciencedirect.com/science/article/pii/S0301008220301969)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:106694
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:17 Nov 2020 17:22
Last Modified:12 Mar 2021 20:24

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