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Viscoelastic Phase Patterning in Artificial Protein Hydrogels

Rapp, Peter B. and Silverman, Bradley R. (2022) Viscoelastic Phase Patterning in Artificial Protein Hydrogels. Macromolecules, 55 (8). pp. 3201-3207. ISSN 0024-9297. doi:10.1021/acs.macromol.2c00094. https://resolver.caltech.edu/CaltechAUTHORS:20201120-110112681

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Abstract

Viscoelastic forces can affect the dynamics of pattern formation during phase separation in polymeric materials. We programmed an artificial protein hydrogel to undergo viscoelastic phase separation above a critical temperature. Highly dynamic phase patterns that coarsened under the influence of viscoelastic stresses spontaneously emerged in these gels. Local oxidative cross-linking promoted by mild photobleaching could be used to initiate phase separation locally, enabling the creation of nonequilibrium patterns that evolved under the influence of surface tension and viscoelastic stresses to yield dynamic structures of controlled size and shape.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1021/acs.macromol.2c00094DOIArticle
https://doi.org/10.26434/chemrxiv.13250102.v1DOIDiscussion Paper
ORCID:
AuthorORCID
Rapp, Peter B.0000-0002-9586-2126
Silverman, Bradley R.0000-0002-9256-8941
Additional Information:© 2022 American Chemical Society. Received: January 14, 2022; Revised: March 23, 2022; Published: April 11, 2022. The assistance of Andres Collazo of the Biological Imaging Facility of the Beckman Institute at the California Institute of Technology is gratefully acknowledged. We thank David Tirrell for providing laboratory space, supplies, and equipment. We also thank David Tirrell, Cole DeForest, John Bagert, and Kai Yuet for helpful discussions and suggestions during the preparation of the manuscript. This work was supported by Grant Number DMR-1506483 from the Biomaterials Program of the U.S. National Science Foundation. The authors declare no competing financial interest.
Funders:
Funding AgencyGrant Number
NSFDMR-1506483
Subject Keywords:Stress, Phase separation, Photobleaching, Fluorescence, Phase transitions
Issue or Number:8
DOI:10.1021/acs.macromol.2c00094
Record Number:CaltechAUTHORS:20201120-110112681
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20201120-110112681
Official Citation:Viscoelastic Phase Patterning in Artificial Protein Hydrogels. Peter B. Rapp and Bradley R. Silverman. Macromolecules 2022 55 (8), 3201-3207; DOI: 10.1021/acs.macromol.2c00094
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:106758
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:20 Nov 2020 19:38
Last Modified:10 May 2022 16:12

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