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The effect of helper virus on Abelson virus-induced transformation of lymphoid cells

Rosenberg, Naomi and Baltimore, David (1978) The effect of helper virus on Abelson virus-induced transformation of lymphoid cells. Journal of Experimental Medicine, 147 (4). pp. 1126-1141. ISSN 0022-1007. PMCID PMC2184241. https://resolver.caltech.edu/CaltechAUTHORS:ROSjem78

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Abstract

Abelson murine leukemia virus (A-MuLV)-transformed fibroblast nonproducer cells were used to prepare A-MuLV stocks containing a number of different helper viruses. The oncogenicity of the A-MuLV stocks was tested by animal inoculation and their ability to transform normal mouse bone marrow cells was measured in vitro. All of the A-MuLV stocks transformed fibroblast cells efficiently. However, only A-MuLV stocks prepared with helper viruses that are highly oncogenic were efficient in vivo and in vitro in hematopoietic cell transformation. In addition, inefficient helpers did not establish a stable infection in lymphoid nonproducer cells. Thus, helper virus has a more central role in lymphoid cell transformation than in fibroblast cell transformation.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1084/jem.147.4.1126DOIArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/pmc2184241/PubMed CentralArticle
ORCID:
AuthorORCID
Baltimore, David0000-0001-8723-8190
Additional Information:© 1978 by Rockefeller University Press. eginning six months after publication, RUP grants the public the non-exclusive right to copy, distribute, or display the Work under a Creative Commons Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/ and http://creativecommons.org/licenses/by-nc-sa/3.0/legalcode. Received for publication 9 November 1977. We thank Daniel Clark for excellent technical assistance. Supported by grant no. VC-41 from the American Cancer Society and grant no. CA-14051 from the National Cancer Institute. [N.R. was a] Postdoctoral fellow of the American Cancer Society, Massachusetts Division. [D.B. was an] American Cancer Society Professor of Microbiology.
Funders:
Funding AgencyGrant Number
American Cancer SocietyVC-41
NIHCA-14051
American Cancer Society, Massachusetts DivisionUNSPECIFIED
Issue or Number:4
PubMed Central ID:PMC2184241
Record Number:CaltechAUTHORS:ROSjem78
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:ROSjem78
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:10676
Collection:CaltechAUTHORS
Deposited By: Archive Administrator
Deposited On:03 Jun 2008
Last Modified:08 Jul 2020 21:44

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