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Molecular genetics of androgen-inducible RP2 gene transcription in the mouse kidney

Rheaume, Carol and Barbour, Karen W. and Tseng-Crank, Julie and Berger, Franklin G. (1989) Molecular genetics of androgen-inducible RP2 gene transcription in the mouse kidney. Molecular and Cellular Biology, 9 (2). pp. 477-483. ISSN 0270-7306.

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Androgen control of the RP2 gene in the mouse kidney has been modified during evolution. In inbred mice (Mus domesticus), the concentrations of mRNAs encoded by RP2 undergo a 10- to 12-fold induction in response to testosterone; in other Mus species (e.g., Mus hortulanus and Mus caroli), induction ranges from none to about two- to fourfold. In this communication, we show that androgens induced RP2 transcription in M. domesticus, although this induction may not have fully accounted for the increase in mRNA levels. Reduced mRNA inducibility in M. hortulanus and in several other species was associated with an absence of transcriptional induction. Analysis of an interspecies backcross population indicated that the difference in RP2 inducibility between M. domesticus and M. hortulanus was due to a single Mendelian locus tightly linked (0 of 47 recombinants) to RP2. The RP2 gene was found to contain at least two promoters, only one of which was highly sensitive to testosterone. These results indicate that induction of the RP2 mRNAs, as well as interspecies variations in RP2 inducibility, are primarily a consequence of effects on this promoter.

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Additional Information:Copyright © 1989 by the American Society for Microbiology. Received 4 August 1988/Accepted 28 October 1988. We thank V. Chapman for providing the backcross animals, B. Parker and C. Schonfeld for technical assistance, and K. French for secretarial work. This work was supported by Public Health Service grant DK-37265 from the National Institute of Diabetes and Digestive and Kidney Diseases.
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Deposited On:03 Jun 2008
Last Modified:03 Oct 2019 00:12

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