Ciechanover, Aaron and Finley, Daniel and Varshavsky, Alexander (1984) The ubiquitin-mediated proteolytic pathway and mechanisms of energy‐dependent intracellular protein degradation. Journal of Cellular Biochemistry, 24 (1). pp. 27-53. ISSN 0730-2312. doi:10.1002/jcb.240240104. https://resolver.caltech.edu/CaltechAUTHORS:20201201-102219067
Full text is not posted in this repository. Consult Related URLs below.
Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20201201-102219067
Abstract
In this review we briefly describe the lysosomal system, consider the evidence for multiplicity of protein degradation pathways in vivo, discuss in detail the ubiquitin‐mediated pathway of intracellular ATP‐dependent protein degradation, and also the possible significance of ubiquitin‐histone conjugates in chromatin. For detailed discussions of the various characteristics and physiological roles of intracellular protein breakdown, the reader is referred to earlier reviews [1–7] and reports of recent symposia [8–10]. Information on the ubiquitin system prior to 1981 was described in an earlier review [11]. Hershko has briefly reviewed more recent information [12].
Item Type: | Article | ||||||
---|---|---|---|---|---|---|---|
Related URLs: |
| ||||||
ORCID: |
| ||||||
Additional Information: | © 1984 Alan R. Liss, Inc. Manuscript accepted: 25 October 1983; Manuscript revised: 25 October 1983; Manuscript received: 13 June 1983. | ||||||
Subject Keywords: | ubiquitin; intracellular protein degradation; chromosome function | ||||||
Issue or Number: | 1 | ||||||
DOI: | 10.1002/jcb.240240104 | ||||||
Record Number: | CaltechAUTHORS:20201201-102219067 | ||||||
Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20201201-102219067 | ||||||
Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||
ID Code: | 106859 | ||||||
Collection: | CaltechAUTHORS | ||||||
Deposited By: | Tony Diaz | ||||||
Deposited On: | 02 Dec 2020 21:58 | ||||||
Last Modified: | 16 Nov 2021 18:57 |
Repository Staff Only: item control page