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The ubiquitin-mediated proteolytic pathway and mechanisms of energy‐dependent intracellular protein degradation

Ciechanover, Aaron and Finley, Daniel and Varshavsky, Alexander (1984) The ubiquitin-mediated proteolytic pathway and mechanisms of energy‐dependent intracellular protein degradation. Journal of Cellular Biochemistry, 24 (1). pp. 27-53. ISSN 0730-2312. doi:10.1002/jcb.240240104. https://resolver.caltech.edu/CaltechAUTHORS:20201201-102219067

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Abstract

In this review we briefly describe the lysosomal system, consider the evidence for multiplicity of protein degradation pathways in vivo, discuss in detail the ubiquitin‐mediated pathway of intracellular ATP‐dependent protein degradation, and also the possible significance of ubiquitin‐histone conjugates in chromatin. For detailed discussions of the various characteristics and physiological roles of intracellular protein breakdown, the reader is referred to earlier reviews [1–7] and reports of recent symposia [8–10]. Information on the ubiquitin system prior to 1981 was described in an earlier review [11]. Hershko has briefly reviewed more recent information [12].


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1002/jcb.240240104DOIArticle
ORCID:
AuthorORCID
Varshavsky, Alexander0000-0002-4011-258X
Additional Information:© 1984 Alan R. Liss, Inc. Manuscript accepted: 25 October 1983; Manuscript revised: 25 October 1983; Manuscript received: 13 June 1983.
Subject Keywords:ubiquitin; intracellular protein degradation; chromosome function
Issue or Number:1
DOI:10.1002/jcb.240240104
Record Number:CaltechAUTHORS:20201201-102219067
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20201201-102219067
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:106859
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:02 Dec 2020 21:58
Last Modified:16 Nov 2021 18:57

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