CaltechAUTHORS
  A Caltech Library Service

Homozygotes for the hereditary persistence of fetal hemoglobin: The ratio of ^Gγ to ^Aγ chains and biosynthetic studies

Ringelhann, B. and Acquaye, C. T. A. and Oldham, J. H. and Konotey-Ahulu, F. I. D. and Yawson, G. and Sukumaran, P. K. and Schroeder, W. A. and Huisman, T. H. J. (1977) Homozygotes for the hereditary persistence of fetal hemoglobin: The ratio of ^Gγ to ^Aγ chains and biosynthetic studies. Biochemical Genetics, 15 (11-12). pp. 1083-1096. ISSN 0006-2928. https://resolver.caltech.edu/CaltechAUTHORS:20201201-130559876

Full text is not posted in this repository. Consult Related URLs below.

Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20201201-130559876

Abstract

Two sons of a previously reported Ghanaian homozygote for the hereditary persistence of fetal hemoglobin (HPFH) (Ringelhann et al., 1970) also are HPFH homozygotes. In addition, another unrelated adult Ghanaian homozygote has been detected. All of these Ghanaian homozygotes as well as three American Black HPFH homozygotes have the ^Gγ^Aγ type of HPFH with a ^Gγ to ^Aγ ratio of about 3:2, in contrast to an Asiatic Indian homozygote who has the ^Gγ type. Globin chain synthesis in HPFH homozygotes is unbalanced, with a γ/α ratio of 0.6 or less, whereas it is balanced in heterozygotes according to most reports.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1007/bf00484499DOIArticle
Alternate Title:Homozygotes for the hereditary persistence of fetal hemoglobin: The ratio of Gγ to Aγ chains and biosynthetic studies
Additional Information:© 1977 Springer. Received 20 January 1977; Accepted 25 April 1977.
Subject Keywords:HPFH homozgote; γ-chain type; globin chain synthesis
Issue or Number:11-12
Record Number:CaltechAUTHORS:20201201-130559876
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20201201-130559876
Official Citation:Ringelhann, B., Acquaye, C.T.A., Oldham, J.H. et al. Homozygotes for the hereditary persistence of fetal hemoglobin: The ratio of Gγ to Aγ chains and biosynthetic studies. Biochem Genet 15, 1083–1096 (1977). https://doi.org/10.1007/BF00484499
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:106868
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:02 Dec 2020 17:43
Last Modified:02 Dec 2020 17:43

Repository Staff Only: item control page