Ringelhann, B. and Acquaye, C. T. A. and Oldham, J. H. and Konotey-Ahulu, F. I. D. and Yawson, G. and Sukumaran, P. K. and Schroeder, W. A. and Huisman, T. H. J. (1977) Homozygotes for the hereditary persistence of fetal hemoglobin: The ratio of ^Gγ to ^Aγ chains and biosynthetic studies. Biochemical Genetics, 15 (11-12). pp. 1083-1096. ISSN 0006-2928. doi:10.1007/bf00484499. https://resolver.caltech.edu/CaltechAUTHORS:20201201-130559876
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Abstract
Two sons of a previously reported Ghanaian homozygote for the hereditary persistence of fetal hemoglobin (HPFH) (Ringelhann et al., 1970) also are HPFH homozygotes. In addition, another unrelated adult Ghanaian homozygote has been detected. All of these Ghanaian homozygotes as well as three American Black HPFH homozygotes have the ^Gγ^Aγ type of HPFH with a ^Gγ to ^Aγ ratio of about 3:2, in contrast to an Asiatic Indian homozygote who has the ^Gγ type. Globin chain synthesis in HPFH homozygotes is unbalanced, with a γ/α ratio of 0.6 or less, whereas it is balanced in heterozygotes according to most reports.
| Item Type: | Article | ||||||
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| Alternate Title: | Homozygotes for the hereditary persistence of fetal hemoglobin: The ratio of Gγ to Aγ chains and biosynthetic studies | ||||||
| Additional Information: | © 1977 Springer. Received 20 January 1977; Accepted 25 April 1977. | ||||||
| Subject Keywords: | HPFH homozgote; γ-chain type; globin chain synthesis | ||||||
| Issue or Number: | 11-12 | ||||||
| DOI: | 10.1007/bf00484499 | ||||||
| Record Number: | CaltechAUTHORS:20201201-130559876 | ||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20201201-130559876 | ||||||
| Official Citation: | Ringelhann, B., Acquaye, C.T.A., Oldham, J.H. et al. Homozygotes for the hereditary persistence of fetal hemoglobin: The ratio of Gγ to Aγ chains and biosynthetic studies. Biochem Genet 15, 1083–1096 (1977). https://doi.org/10.1007/BF00484499 | ||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||
| ID Code: | 106868 | ||||||
| Collection: | CaltechAUTHORS | ||||||
| Deposited By: | Tony Diaz | ||||||
| Deposited On: | 02 Dec 2020 17:43 | ||||||
| Last Modified: | 16 Nov 2021 18:57 |
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