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SARS-CoV-2 B cell receptor signatures in risk populations

Flyak, Andrew I. (2021) SARS-CoV-2 B cell receptor signatures in risk populations. Journal of Clinical Investigation, 131 (1). Art. No. e144685. ISSN 0021-9738. PMCID PMC7773361. doi:10.1172/JCI144685.

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Many individuals possess B cells capable of recognizing epitopes on the spike glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this issue of the JCI, Paschold and Simnica et al. interrogated the frequency of SARS-CoV-2–specific B cell receptor rearrangements in healthy subjects based on age and cancer status. The authors found that while SARS-CoV-2–specific antibody signatures can be identified in the repertoires of young, healthy individuals, such sequences are less frequent in elderly subjects or patients with cancer. Overall, this study sheds light on B cell repertoire restrictions that might lead to an unfavorable clinical course of coronavirus disease 2019 infection in at-risk populations.

Item Type:Article
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URLURL TypeDescription CentralArticle
Flyak, Andrew I.0000-0002-8722-479X
Additional Information:© 2021 American Society for Clinical Investigation. Published November 20, 2020. AIF is supported by a research funding from the National Institutes of Health grant K99 AI153465 (content is solely the responsibility of the author and does not necessarily represent the official views of the NIH). AIF acknowledges Pamela J. Bjorkman for critical reading of the manuscript. The author has declared that no conflict of interest exists.
Funding AgencyGrant Number
NIHK99 AI153465
Issue or Number:1
PubMed Central ID:PMC7773361
Record Number:CaltechAUTHORS:20201202-081646342
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Official Citation:SARS-CoV-2 B cell receptor signatures in risk populations; J Clin Invest. 2021;131(1):e144685.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:106872
Deposited By: Tony Diaz
Deposited On:02 Dec 2020 16:35
Last Modified:11 Feb 2022 22:20

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