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Stimulus-selective lateral signaling between olfactory afferents enables parallel encoding of distinct CO₂ dynamics

Zocchi, Dhruv and Hong, Elizabeth J. (2020) Stimulus-selective lateral signaling between olfactory afferents enables parallel encoding of distinct CO₂ dynamics. . (Unpublished) https://resolver.caltech.edu/CaltechAUTHORS:20201204-110354387

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Abstract

An important problem in sensory processing is how lateral interactions that mediate the integration of information across sensory channels function with respect to their stimulus tunings. We demonstrate a novel form of stimulus-selective crosstalk between olfactory channels that occurs between primary olfactory receptor neurons (ORNs). Neurotransmitter release from ORNs can be driven by two distinct sources of excitation, feedforward activity derived from the odorant receptor and lateral input originating from specific subsets of other ORNs. Consequently, levels of presynaptic release can become dissociated from firing rate. Stimulus-selective lateral signaling results in the distributed representation of CO₂, a behaviorally important environmental cue that elicits spiking in only a single ORN class, across multiple olfactory channels. Different CO₂-responsive channels preferentially transmit distinct stimulus dynamics, thereby expanding the coding bandwidth for CO₂. These results generalize to additional odors and olfactory channels, revealing a subnetwork of lateral interactions between ORNs that reshape the spatial and temporal structure of odor representations in a stimulus-specific manner.


Item Type:Report or Paper (Discussion Paper)
Related URLs:
URLURL TypeDescription
https://doi.org/10.1101/2020.12.03.410571DOIDiscussion Paper
Alternate Title:Stimulus-selective lateral signaling between olfactory afferents enables parallel encoding of distinct CO2 dynamics
Additional Information:The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license. We are grateful to B. D. Pfeiffer and D. J. Anderson for gifts of unpublished fly stocks. We thank T. Lee, and R. J. Wyman for sharing fly stocks, and we thank G. Rubin and L. M. Stevens for sharing plasmids. We thank A. Dea for the generation of the lexAop-DTI flies. We thank M. Meister and P. W. Sternberg for helpful comments, and M. H. Dickinson and members of the Hong lab for careful readings of the manuscript. We especially acknowledge F. van Breugel and M. H. Dickinson for stimulating conversations and for sharing unpublished results which partially motivated this study. This work was funded by grants to E. J. H. from the National Science Foundation (Ideas Lab 1556230), the National Institutes of Health (1U01MH109147), and the Shurl and Kay Curci Foundation. E. J. H. is a Clare Boothe Luce Professor of the Henry Luce Foundation. AUTHOR CONTRIBUTIONS. Dhruv Zocchi: Conceptualization, Methodology, Investigation, Validation, Formal analysis, Writing – Original Draft, Writing – Review & Editing, Visualization. Elizabeth J. Hong: Conceptualization, Methodology, Formal analysis, Writing – Original Draft, Writing – Review & Editing, Visualization, Supervision, Funding acquisition. The authors declare no competing interests.
Funders:
Funding AgencyGrant Number
NSFIOS-1556230
NIH1U01MH109147
Shurl and Kay Curci FoundationUNSPECIFIED
Henry Luce FoundationUNSPECIFIED
Subject Keywords:sensory processing, primary afferents, olfactory receptor neuron, Drosophila, carbon dioxide, lateral interactions, antennal lobe, temporal filtering, stimulus dynamics
Record Number:CaltechAUTHORS:20201204-110354387
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20201204-110354387
Official Citation:Stimulus-selective lateral signaling between olfactory afferents enables parallel encoding of distinct CO2 dynamics Dhruv Zocchi, Elizabeth J Hong bioRxiv 2020.12.03.410571; doi: https://doi.org/10.1101/2020.12.03.410571
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:106904
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:05 Dec 2020 02:27
Last Modified:05 Dec 2020 02:27

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