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Prenatal exposure and transplacental transfer of perfluoroalkyl substance isomers in participants from the upper and lower reaches of the Yangtze River

Liu, Yingxue and Liu, Kai and Zheng, Ping and Yin, Shanshan and Jin, Hangbiao and Bai, Xiaoxia and Li, Yongqing and Zheng, Jingxian and Dai, Yishuang and Zhao, Meirong and Liu, Weiping (2021) Prenatal exposure and transplacental transfer of perfluoroalkyl substance isomers in participants from the upper and lower reaches of the Yangtze River. Environmental Pollution, 270 . Art. No. 116202. ISSN 0269-7491. https://resolver.caltech.edu/CaltechAUTHORS:20201208-105038519

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Abstract

Data on gestational exposure characteristics and transplacental transfer are quite limited for perfluoroalkyl substance (PFAS) isomers, especially those from large-scale comparative studies. To fill this gap, we examined isomers of perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), and perfluorohexane sulfonic acid (PFHxS) in matched maternal and cord serum from Mianyang and Hangzhou, which are located in the upper and lower reaches of the Yangtze River, China, respectively. These data were compared with those from our previous study on Wuhan in the middle reach. The average ΣPFAS concentration increased from upstream to downstream (Mianyang (4.44 ng/mL) < Wuhan (9.88 ng/mL) < Hangzhou (19.72 ng/mL)) and may be related to the per capita consumption expenditure of each city. The ln-transformed PFAS concentrations showed significant differences between Mianyang and Hangzhou after adjusting confounding factors (p < 0.05). The percentages of linear PFOS and PFOA in maternal and cord serum from these cities all exceeded those in electrochemical fluorination products. The isomer profiles of PFASs in maternal and cord serum might be greatly influenced by local production processes of PFASs and residents’ dietary habits. The transplacental transfer efficiencies decreased significantly with increasing concentrations in maternal serum for ΣPFAS, ΣPFOS, ΣPFOA, ΣPFHxS, n-PFOS, iso-PFOS, 4m-PFOS, 1m-PFOS, n-PFOA, n-PFHxS, and br-PFHxS (Spearman rank correlation coefficients (r) = 0.373–0.687, p < 0.01). These findings support an understanding of the regional characteristics in maternal exposure to PFASs along the Yangtze River, isomeric profiles of PFASs in these regions, and the transplacental transfer processes of PFAS isomers.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/j.envpol.2020.116202DOIArticle
ORCID:
AuthorORCID
Liu, Kai0000-0002-2109-8196
Yin, Shanshan0000-0001-8859-9852
Liu, Weiping0000-0002-1173-892X
Additional Information:© 2020 Elsevier. Received 12 August 2020, Revised 27 November 2020, Accepted 29 November 2020, Available online 6 December 2020. This work was supported by the National Natural Science Foundation of China (No. 21976157, No. 21777137, and No. 81671478) as well as the Creative Research Group Fund (No. 21621005). We sincerely thank the doctors and nurses at the Women’s Hospital School of Medicine Zhejiang University and the Mianyang Municipal Maternal and Child Health-Care Hospital and for collecting the maternal and cord serum. We also thank the voluntary mothers for participating in this study. The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Funders:
Funding AgencyGrant Number
National Natural Science Foundation of China21976157
National Natural Science Foundation of China21777137
National Natural Science Foundation of China81671478
National Natural Science Foundation of China21621005
Subject Keywords:PFOS; PFOA; PFHxS; isomers; transplacental transfer; the Yangtze River
Record Number:CaltechAUTHORS:20201208-105038519
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20201208-105038519
Official Citation:Yingxue Liu, Kai Liu, Ping Zheng, Shanshan Yin, Hangbiao Jin, Xiaoxia Bai, Yongqing Li, Jingxian Zheng, Yishuang Dai, Meirong Zhao, Weiping Liu, Prenatal exposure and transplacental transfer of perfluoroalkyl substance isomers in participants from the upper and lower reaches of the Yangtze River, Environmental Pollution, Volume 270, 2021, 116202, ISSN 0269-7491, https://doi.org/10.1016/j.envpol.2020.116202. (http://www.sciencedirect.com/science/article/pii/S0269749120368913)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:106964
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:09 Dec 2020 17:11
Last Modified:21 Dec 2020 18:22

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