CaltechAUTHORS
  A Caltech Library Service

Principles of Self-Organization of the Mammalian Embryo

Zhu, Meng and Zernicka-Goetz, Magdalena (2020) Principles of Self-Organization of the Mammalian Embryo. Cell, 183 (6). pp. 1467-1478. ISSN 0092-8674. https://resolver.caltech.edu/CaltechAUTHORS:20201210-160239379

Full text is not posted in this repository. Consult Related URLs below.

Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20201210-160239379

Abstract

Early embryogenesis is a conserved and self-organized process. In the mammalian embryo, the potential for self-organization is manifested in its extraordinary developmental plasticity, allowing a correctly patterned embryo to arise despite experimental perturbation. The underlying mechanisms enabling such regulative development have long been a topic of study. In this Review, we summarize our current understanding of the self-organizing principles behind the regulative nature of the early mammalian embryo. We argue that geometrical constraints, feedback between mechanical and biochemical factors, and cellular heterogeneity are all required to ensure the developmental plasticity of mammalian embryo development.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/j.cell.2020.11.003DOIArticle
ORCID:
AuthorORCID
Zhu, Meng0000-0001-6157-8840
Zernicka-Goetz, Magdalena0000-0002-7004-2471
Additional Information:© 2020 Published by Elsevier. Available online 10 December 2020. We thank David Glover, Marta Shahbazi, Berna Sozen, Adiyant Lamba, and Min Bao for the constructive comments on the review. The work in the M.Z.-G. lab is supported by Wellcome Trust (098287/Z/12/Z), ERC (669198), Luverhulme Trust (RPG-2018-085), National Institutes of Health (R01 HD100456-01A1, 1DP1HD104575-01), Curci and Weston Havens Foundations, and Open Philanthropy grants.
Funders:
Funding AgencyGrant Number
Wellcome Trust098287/Z/12/Z
European Research Council (ERC)669198
Luverhulme TrustRPG-2018-085
NIHR01 HD100456-01A1
NIH1DP1HD104575-01
Shurl and Kay Curci FoundationUNSPECIFIED
Weston Havens FoundationUNSPECIFIED
Open PhilanthropyUNSPECIFIED
Issue or Number:6
Record Number:CaltechAUTHORS:20201210-160239379
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20201210-160239379
Official Citation:Meng Zhu, Magdalena Zernicka-Goetz, Principles of Self-Organization of the Mammalian Embryo, Cell, Volume 183, Issue 6, 2020, Pages 1467-1478, ISSN 0092-8674, https://doi.org/10.1016/j.cell.2020.11.003.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:107022
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:11 Dec 2020 15:35
Last Modified:11 Dec 2020 15:35

Repository Staff Only: item control page