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Heart rate and blood pressure decreases after a motor task in pre‐symptomatic AD

Rochart, Roger and Liu, Quanying and Doyle, John C. and Arechavala, Rebecca Johnson and Kloner, Robert and Kleinman, Michael T. and Harrington, Michael G. and Arakaki, Xianghong (2020) Heart rate and blood pressure decreases after a motor task in pre‐symptomatic AD. Alzheimer's & Dementia, 16 (S5, pt 2). Art. No. e045521. ISSN 1552-5260. https://resolver.caltech.edu/CaltechAUTHORS:20201210-160240164

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Abstract

Background. Understanding how cardiovascular health affects the early Alzheimer’s disease (AD) pathology is challenging because several variables can contribute to significant changes in blood pressure (BP) and heart rate (HR). Previous studies have suggested an association between Alzheimer's disease and HR. Little association is known about pre‐symptomatic AD. We aim to explore the HR and BP changes before and after a motor task in a cognitive healthy population. Method. Participants (age ranged 61‐95 years old) were recruited from the local community, including cognitively healthy (CH) individuals who were further subdivided based on cerebrospinal fluid (CSF) classification: those with a normal amyloid/tau ratio (CH‐NAT, n = 11) or a pathological amyloid/tau ratio (CH‐PAT, n = 8). Two groups were age, gender, BMI, and education matched. Participants were asked to use a steering wheel to follow a moving line presented on the monitor. Practice session were followed by three task‐identical sessions, 90 seconds per session. Each session consisted of 3 repeated blocks, 30 seconds per block: bump, trail, and bump & trail. Systolic pressure (SP), diastolic pressure (DP), pulse pressure (PP), and HR were measured before and after completing the whole task. Result. No differences in BP and HR were found between CH‐NATs and CH‐PATs. We found a significant decrease in SP for both CH‐NATs (pre‐task 135.2±24.2, post‐task 127.2±18.8, reduced by 8±9.7, p = 0.0208) and CH‐PATs (pre‐task: 146.1±20.6, post‐task: 134.8±19.6, reduced by 11.3±5.2, p = 0.0004). Furthermore, CH‐PATs have a significant drop in HR (pre‐task: 71.4±10.7, post‐task: 66.3±8.2, reduced by 5.1±4.1 beats, p = 0.0098) compared to CH‐NATs (pre‐task: 70.8±11.8, post‐task: 69.2±13.3, reduced by 1.5±6.2 beats, p = 0.4302). CH‐PATs has decreased HR*SP (pre‐task: 10464±2375.6, post‐task: 8941.1±1843.1, reduced by 1522.9±775.8, p = 0.0009), compared to CH‐NATs (pre‐task: 9537.2±2098.3, post‐task: 8765.2±1769.2, reduced by 772.0±1153.5, p=0.0507). No significant change was found in DP for either CH‐NATs or CH‐PATs. Conclusion. Pre‐symptomatic AD participants have a significant drop of HR, SP, and SP*HR compared to CH‐NATs, indicating reduced sympathetic responses after motor task. These changes in HR and SP may provide evidence of compromised cardiovascular health and autonomic regulation in pre‐symptomatic AD.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1002/alz.045521DOIArticle
ORCID:
AuthorORCID
Liu, Quanying0000-0002-2501-7656
Doyle, John C.0000-0002-1828-2486
Arechavala, Rebecca Johnson0000-0002-9799-2610
Kloner, Robert0000-0002-6258-0544
Harrington, Michael G.0000-0002-7923-8032
Arakaki, Xianghong0000-0003-0721-7168
Additional Information:© 2020 the Alzheimer's Association. Issue Online: 07 December 2020. Version of Record online: 07 December 2020.
Issue or Number:S5, pt 2
Record Number:CaltechAUTHORS:20201210-160240164
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20201210-160240164
Official Citation:Rochart, R., Liu, Q., Doyle, J.C., Arechavala, R.J., Kloner, R., Kleinman, M.T., Harrington, M.G. and Arakaki, X. (2020), Heart rate and blood pressure decreases after a motor task in pre‐symptomatic AD. Alzheimer's Dement., 16: e045521. https://doi.org/10.1002/alz.045521
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:107027
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:11 Dec 2020 15:26
Last Modified:11 Dec 2020 15:26

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