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Interaction between directional epistasis and average mutational effects

Wilke, Claus O. and Christoph, Adami (2001) Interaction between directional epistasis and average mutational effects. Proceedings of the Royal Society of London. Series B, Biological Sciences, 268 (1475). pp. 1469-1474. ISSN 0962-8452. PMCID PMC1088765. doi:10.1098/rspb.2001.1690.

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We investigate the relationship between the average fitness decay due to single mutations and the strength of epistatic interactions in genetic sequences. We observe that epistatic interactions between mutations are correlated to the average fitness decay, both in RNA secondary structure prediction as well as in digital organisms replicating in silico. This correlation implies that, during adaptation, epistasis and average mutational effect cannot be optimized independently. In experiments with RNA sequences evolving on a neutral network, the selective pressure to decrease the mutational load then leads to a reduction in the amount of sequences with strong antagonistic interactions between deleterious mutations in the population.

Item Type:Article
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URLURL TypeDescription CentralArticle
Wilke, Claus O.0000-0002-7470-9261
Christoph, Adami0000-0002-2915-9504
Additional Information:© 2002 The Royal Society. Published online: 22/07/2001; Published in print: 22/07/2001. We thank Martijn Huynen for providing access to the sequences used in Van Nimwegen et al. (1999) and Walter Fontana for providing us with his flow reactor code. We are grateful to Richard Lenski and two anonymous referees for many useful comments and suggestions regarding the manuscript. The genomes of digital organisms used in this study are available at This work was supported by the National Science Foundation under contract no. DEB-9981397.
Funding AgencyGrant Number
Subject Keywords:Epistasis; digital organisms; neutrality; RNA structure folding; digital organisms
Issue or Number:1475
PubMed Central ID:PMC1088765
Record Number:CaltechAUTHORS:20201215-153415616
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Official Citation:Wilke Claus O. and Christoph Adami. 2001. Interaction between directional epistasis and average mutational effects. Proc. R. Soc. Lond. B. 268: 1469–1474.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:107107
Deposited By: Jason Perez
Deposited On:16 Dec 2020 16:46
Last Modified:16 Nov 2021 18:59

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