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Very long stretches of free DNA in chromatin

Varshavsky, A. J. and Ilyin, Yu. V. and Georgiev, G. P. (1974) Very long stretches of free DNA in chromatin. Nature, 250 (5467). pp. 602-606. ISSN 0028-0836. doi:10.1038/250602a0.

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The arrangement of histones along the DNA in chromosomes has been studied using digestion of the chromatin with DNase and titration of the chromatin with polylysine or certain dyes as probes. The precision of these probes is limited by the extent to which DNA partially covered with histones will react with the enzymes or titration agents used. Furthermore, it has been noted that histones are redistributed along or between DNA fibres under conditions arising during the normal course of isolation and handling of the chromatin. This phenomenon may have strongly influenced the results obtained previously.

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Varshavsky, A. J.0000-0002-4011-258X
Additional Information:© 1974 Nature Publishing Group. Received May 1, 1973; revised January 31, 1974. We thank V. V. Bakayev and A. A. Bayev, jun. for collaboration at later stages of the work, Dr V. N. Soyfer for providing ultracentrifuge facilities and N. N. Dohbert for technical assistance.
Issue or Number:5467
Record Number:CaltechAUTHORS:20201216-124002260
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Official Citation:VARSHAVSKY, A., ILYIN, Y. & GEORGIEV, G. Very long stretches of free DNA in chromatin. Nature 250, 602–606 (1974).
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:107126
Deposited By: George Porter
Deposited On:16 Dec 2020 21:25
Last Modified:16 Nov 2021 18:59

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