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The dynamics of morphogenesis in stem cell-based embryology: Novel insights for symmetry breaking

Sozen, Berna and Cornwall-Scoones, Jake and Zernicka-Goetz, Magdalena (2021) The dynamics of morphogenesis in stem cell-based embryology: Novel insights for symmetry breaking. Developmental Biology, 474 . pp. 82-90. ISSN 0012-1606. PMCID PMC8259461. doi:10.1016/j.ydbio.2020.12.005.

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Breaking embryonic symmetry is an essential prerequisite to shape the initially symmetric embryo into a highly organized body plan that serves as the blueprint of the adult organism. This critical process is driven by morphogen signaling gradients that instruct anteroposterior axis specification. Despite its fundamental importance, what triggers symmetry breaking and how the signaling gradients are established in time and space in the mammalian embryo remain largely unknown. Stem cell-based in vitro models of embryogenesis offer an unprecedented opportunity to quantitatively dissect the multiple physical and molecular processes that shape the mammalian embryo. Here we review biochemical mechanisms governing early mammalian patterning in vivo and highlight recent advances to recreate this in vitro using stem cells. We discuss how the novel insights from these model systems extend previously proposed concepts to illuminate the extent to which embryonic cells have the intrinsic capability to generate specific, reproducible patterns during embryogenesis.

Item Type:Article
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URLURL TypeDescription CentralArticle
Sozen, Berna0000-0001-5834-5819
Cornwall-Scoones, Jake0000-0002-7435-486X
Zernicka-Goetz, Magdalena0000-0002-7004-2471
Additional Information:© 2020 Published by Elsevier. Received 29 July 2020, Revised 5 December 2020, Accepted 7 December 2020, Available online 15 December 2020. We thank Andy Cox, David Glover and Meng Zhu for critical reading and insightful comments on the manuscript. We apologize to the many authors whose work we failed to discuss because of space constraints. B.S. is grateful to Yale School of Medicine for start-up funding. M.Z.G. laboratory thank Open Philanthropy, Curci Foundation and Weston Havens Foundation for supporting the research.
Funding AgencyGrant Number
Yale School of MedicineUNSPECIFIED
Open PhilanthropyUNSPECIFIED
Shurl and Kay Curci FoundationUNSPECIFIED
Weston Havens FoundationUNSPECIFIED
Subject Keywords:Stem cells; Embryogenesis; Symmetry breaking; Gastrulation; Signaling; In vitro
PubMed Central ID:PMC8259461
Record Number:CaltechAUTHORS:20201217-133744809
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Official Citation:Berna Sozen, Jake Cornwall-Scoones, Magdalena Zernicka-Goetz, The dynamics of morphogenesis in stem cell-based embryology: Novel insights for symmetry breaking, Developmental Biology, Volume 474, 2021, Pages 82-90, ISSN 0012-1606,
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:107164
Deposited By: George Porter
Deposited On:17 Dec 2020 22:12
Last Modified:08 Sep 2021 16:01

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