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Severe COVID-19 Illness: Risk Factors and Its Burden on Critical Care Resources

Yun, Kyongsik and Lee, Jeong Seok and Kim, Eun Young and Chandra, Himanshu and Oh, Baek-Lok and Oh, Jihoon (2020) Severe COVID-19 Illness: Risk Factors and Its Burden on Critical Care Resources. Frontiers in Medicine, 7 . Art. No. 583060. ISSN 2296-858X. PMCID PMC7711126. doi:10.3389/fmed.2020.583060.

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In South Korea, the first confirmed case of coronavirus 2019 (COVID-19) was detected on January 20, 2020. After a month, the number of confirmed cases surged, as community transmission occurred. The local hospitals experienced severe shortages in medical resources such as mechanical ventilators and extracorporeal membrane oxygenation (ECMO) equipment. With the medical claims data of 7,590 COVID-19 confirmed patients, this study examined how the demand for major medical resources and medications changed during the outbreak and subsequent stabilization period of COVID-19 in South Korea. We also aimed to investigate how the underlying diseases and demographic factors affect disease severity. Our findings revealed that the risk of being treated with a mechanical ventilator or ECMO (critical condition) was almost twice as high in men, and a previous history of hypertension, diabetes, and psychiatric diseases increased the risk for progressing to critical condition [Odds Ratio (95% CI), 1.60 (1.14–2.24); 1.55 (1.55–2.06); 1.73 (1.25–2.39), respectively]. Although chronic pulmonary disease did not significantly increase the risk for severity of the illness, patients with a Charlson comorbidity index score of ≥5 and those treated in an outbreak area had an increased risk of developing a critical condition [3.82 (3.82–8.15); 1.59 (1.20–2.09), respectively]. Our results may help clinicians predict the demand for medical resources during the spread of COVID-19 infection and identify patients who are likely to develop severe disease.

Item Type:Article
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URLURL TypeDescription CentralArticle
Yun, Kyongsik0000-0002-6103-7187
Additional Information:© 2020 Yun, Lee, Kim, Chandra, Oh and Oh. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Received: 18 August 2020; Accepted: 12 October 2020; Published: 19 November 2020. We thank the medical professionals dedicated to treating patients with COVID-19 in Korea, and the Ministry of Health and Welfare and the Health Insurance Review and Assessment Service of Korea for promptly sharing valuable national health insurance claim data. Data Availability Statement: The datasets generated in this study can be found in online repositories. The names of the repository/repositories and accession number(s) can be found below: Ethics Statement: The studies involving human participants were reviewed and approved by The Catholic University of Korea (KC20ZISI0259). Written informed consent for participation was not required for this study in accordance with the national legislation and the institutional requirements. Author Contributions: KY, B-LO, and JO conceived of the presented idea. KY, HC, and B-LO performed and analyzed the dataset. JO, JL, and HC verified the analytical methods. B-LO and JO supervised the findings of this work. All authors discussed the results and contributed to the final manuscript. Funding: This work was partially supported by the Seoul National University Hospital Research Fund (0320202160). Conflict of Interest: JL was employed by GENOME INSIGHT Inc. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Funding AgencyGrant Number
Seoul National University Hospital Research Fund0320202160
Subject Keywords:ECMO—extracorporeal membrane oxygenation, ventilator, severity, COVID-19, hydroxychloroquine
PubMed Central ID:PMC7711126
Record Number:CaltechAUTHORS:20201221-133546033
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Official Citation:Yun K, Lee JS, Kim EY, Chandra H, Oh B-L and Oh J (2020) Severe COVID-19 Illness: Risk Factors and Its Burden on Critical Care Resources. Front. Med. 7:583060. doi: 10.3389/fmed.2020.583060
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:107242
Deposited By: Tony Diaz
Deposited On:21 Dec 2020 23:05
Last Modified:16 Nov 2021 19:00

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