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Heteroduplex analysis of the RNA of clone 3 Moloney murine sarcoma virus

Chen, Yueh-Hsiu and Verma, Inder M. and Duesberg, P. H. and Davidson, Norman (1979) Heteroduplex analysis of the RNA of clone 3 Moloney murine sarcoma virus. Journal of Virology, 32 (3). pp. 1028-1032. ISSN 0022-538X.

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Heteroduplex analysis of the RNA isolated from purified virions of clone 3 Moloney murine sarcoma virus (M-MSV) hybridized to cDNA's from Moloney murine leukemia virus (M-MLV) and clone 124 M-MSV shows that the main physical component of clone 3 RNA is missing all or most of the 1.5-kilobase (kb) clone 124 M-MSV specific sequence denoted beta s (S. Hu et al. Cell 10:469-477, 1977). This sequence is either deleted in clone 3 RNA or substituted by a very short (0.3-kilobase) sequence. In other respects, clone 3 and clone 124 RNAs show the same heteroduplex structure relative to M-MLV. Since beta s is believed to contain the src gene(s) of clone 124 RNA, this result leaves as an unresolved question the nature of the src gene(s) of the clone 3 M-MSV RNA complex.

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Additional Information:Copyright © 1979 by the American Society for Microbiology. Received for publication 25 June 1979. This research has been supported by grants CA 16516, CA 21408, and CA 11426 from the Public Health Service, and contracts NO1-CP-61001 and NO1-CP-43306 from the Virus Cancer Program of the National Cancer Institute. Y.C. was supported in part by a postdoctoral fellowship, F23CA05099, from the National Institutes of Health. We are indebted to D. Donoghue for the open exchange of results before publication.
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Deposited On:05 Jun 2008
Last Modified:03 Oct 2019 00:12

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