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The Interaction of TRAF6 With Neuroplastin Promotes Spinogenesis During Early Neuronal Development

Vemula, Sampath Kumar and Malci, Ayse and Junge, Lennart and Lehmann, Anne-Christin and Rama, Ramya and Hradsky, Johannes and Matute, Ricardo A. and Weber, André and Prigge, Matthias and Naumann, Michael and Kreutz, Michael R. and Seidenbecher, Constanze I. and Gundelfinger, Eckart D. and Herrera-Molina, Rodrigo (2020) The Interaction of TRAF6 With Neuroplastin Promotes Spinogenesis During Early Neuronal Development. Frontiers in Cell and Developmental Biology, 8 . Art. No. 579513. ISSN 2296-634X. PMCID PMC7755605. https://resolver.caltech.edu/CaltechAUTHORS:20210115-132721998

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Abstract

Chagas disease (CD) is a tropical and still neglected disease caused by Trypanosoma cruzi that affects >8 million of people worldwide. Although limited, emerging data suggest that gut microbiota dysfunction may be a new mechanism underlying CD pathogenesis. T. cruzi infection leads to changes in the gut microbiota composition of vector insects, mice, and humans. Alterations in insect and mice microbiota due to T. cruzi have been associated with a decreased immune response against the parasite, influencing the establishment and progression of infection. Further, changes in the gut microbiota are linked with inflammatory and neuropsychiatric disorders, comorbid conditions in CD. Therefore, this review article critically analyses the current data on CD and the gut microbiota of insects, mice, and humans and discusses its importance for CD pathogenesis. An enhanced understanding of host microbiota will be critical for the development of alternative therapeutic approaches to target CD, such as gut microbiota-directed interventions.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.3389/fcell.2020.579513DOIArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/pmc7755605/PubMed CentralArticle
https://www.frontiersin.org/articles/10.3389/fcell.2020.579513/full#supplementary-materialPublisherSupporting Information
https://doi.org/10.1101/768341DOIDiscussion Paper
ORCID:
AuthorORCID
Vemula, Sampath Kumar0000-0002-4052-4218
Matute, Ricardo A.0000-0002-0644-3799
Prigge, Matthias0000-0002-4923-0056
Naumann, Michael0000-0002-8060-2313
Kreutz, Michael R.0000-0003-0575-6950
Seidenbecher, Constanze I.0000-0002-7433-2716
Gundelfinger, Eckart D.0000-0001-9377-7414
Herrera-Molina, Rodrigo0000-0001-9597-5131
Alternate Title:TRAF6 controls spinogenesis instructing synapse density and neuronal activity through binding neuroplastin
Additional Information:© 2020 Vemula, Malci, Junge, Lehmann, Rama, Hradsky, Matute, Weber, Prigge, Naumann, Kreutz, Seidenbecher, Gundelfinger and Herrera-Molina. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Received: 02 July 2020; Accepted: 11 November 2020; Published: 09 December 2020. We thank to Kathrin Pohlmann for her technical work and Dirk Montag for providing neuroplastin mice. Preliminary manuscript has been released as a pre-print at bioRxiv (Vemula et al., 2020). This study was supported by funding from the DFG GRK 1167 and the ABINEP graduate school funded by the federal state of Saxony-Anhalt and the European Structural and Investment Funds (ESF, 2014-2020), project number ZS/2016/08/80645 to EG, MN, and CS. RM received funding from FONDECYT Grant No. 1181260. MP was supported by the Leibniz Association (SheLi J28/2017). RH-M is an LSA fellow from the Center for Behavioral Brain Sciences (CBBS) and received the DAAD grant no. 57514679. EG was supported by the DFG SFB 854, and CS and EG received funding from BMBF 01DN17002. Author Contributions. SV and AM conducted most of the experiments and raw data analysis. LJ conducted the PMCA experiments. A-CL and RR made and characterized constructs. JH conducted the SPR experiments. RM conducted the in silico modeling. MP conducted the Patch Clamp experiments. RH-M supported the experiments, conducted the MEA and Patch Clamp experiments, and wrote the manuscript draft. RH-M, MK, MP, MN, CS, and EG contributed to the experimental design and data interpretation. All the authors contributed to the manuscript’s final version. Data Availability Statement. The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Funders:
Funding AgencyGrant Number
Deutsche Forschungsgemeinschaft (DFG)GRK 1167
State of Saxony-AnhaltUNSPECIFIED
European Structural and Investment FundsZS/2016/08/80645
Fondo Nacional de Desarrollo Científico y Tecnológico (FONDECYT)1181260
Leibniz AssociationSheLi J28/2017
Otto von Guericke University MagdeburgUNSPECIFIED
Deutscher Akademischer Austauschdienst (DAAD)57514679
Deutsche Forschungsgemeinschaft (DFG)SFB 854
Bundesministerium für Bildung und Forschung (BMBF)01DN17002
Subject Keywords:dendritic protrusion, neuroplastin, E-I synapse balance, TRAF6, excitatory spinogenesis, synapse formation, neuronal connectivity
PubMed Central ID:PMC7755605
Record Number:CaltechAUTHORS:20210115-132721998
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20210115-132721998
Official Citation:Vemula SK, Malci A, Junge L, Lehmann A-C, Rama R, Hradsky J, Matute RA, Weber A, Prigge M, Naumann M, Kreutz MR, Seidenbecher CI, Gundelfinger ED and Herrera-Molina R (2020) The Interaction of TRAF6 With Neuroplastin Promotes Spinogenesis During Early Neuronal Development. Front. Cell Dev. Biol. 8:579513. doi: 10.3389/fcell.2020.579513
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:107518
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:15 Jan 2021 21:57
Last Modified:15 Jan 2021 21:57

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