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Diadenosine 5′, 5′′′-P¹, P⁴-tetraphosphate: a pleiotropically acting alarmone?

Varshavsky, Alexander (1983) Diadenosine 5′, 5′′′-P¹, P⁴-tetraphosphate: a pleiotropically acting alarmone? Cell, 34 (3). pp. 711-712. ISSN 0092-8674. https://resolver.caltech.edu/CaltechAUTHORS:20210119-114432779

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Abstract

In 1966, Zamecnik and his colleagues found an unusual dinucleotide, diadenosine 5’, 5”‘-P¹, P⁴-tetraphosphate (Apa), synthesized in an in vitro system consisting of ATP, Mg²⁺, L-lysine, and purified E. coli lysyl-tRNA synthetase (Zamecnik et al., BBRC 24, 91-97, 1966). Ap₄A is synthesized in vitro by many, though possibly not all, aminoacyl-tRNA synthetases (aa-tRNA synthetases) through aminoacyladenylate as an obligatory intermediate (reaction 3) (Goerlich et al., Eur. J. Biochem. 726, 13% 142, 1982; Brevet et al., JBC 257, 14611-14615, 1982).


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/0092-8674(83)90526-3DOIArticle
ORCID:
AuthorORCID
Varshavsky, Alexander0000-0002-4011-258X
Alternate Title:Diadenosine 5′, 5′′′-P1, P4-tetraphosphate: a pleiotropically acting alarmone?
Additional Information:© 1983 MIT.
Issue or Number:3
Record Number:CaltechAUTHORS:20210119-114432779
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20210119-114432779
Official Citation:Alexander Varshavsky, Diadenosine 5′, 5′′′-P1, P4-tetraphosphate: a pleiotropically acting alarmone?, Cell, Volume 34, Issue 3, 1983, Pages 711-712, ISSN 0092-8674, https://doi.org/10.1016/0092-8674(83)90526-3.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:107540
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:19 Jan 2021 20:38
Last Modified:19 Jan 2021 20:38

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