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Acoustic Measurements of Nucleus Size Distribution at the Cavitation Threshold

Mancia, Lauren and Rodriguez, Mauro and Sukovich, Jonathan R. and Haskel, Scott and Xu, Zhen and Johnsen, Eric (2021) Acoustic Measurements of Nucleus Size Distribution at the Cavitation Threshold. Ultrasound in Medicine and Biology, 47 (4). pp. 1024-1031. ISSN 0301-5629. https://resolver.caltech.edu/CaltechAUTHORS:20210120-152754721

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Abstract

An understanding of the acoustic cavitation threshold is essential for minimizing cavitation bio-effects in diagnostic ultrasound and for controlling cavitation-mediated tissue ablation in focused ultrasound procedures. The homogeneous cavitation threshold is an intrinsic material property of recognized importance to biomedical ultrasound as well as a variety of other applications requiring cavitation control. However, measurements of the acoustic cavitation threshold in water differ from those predicted by classic nucleation theories. This persistent discrepancy is explained by combining recently developed methods for acoustically nucleating single bubbles at threshold with numerical modeling to obtain a nucleus size distribution consistent with first-principles estimates for ion-stabilized nuclei. We identify acoustic cavitation at threshold as a reproducible subtype of heterogeneous cavitation with a characteristic nucleus size distribution. Knowledge of the nucleus size distribution could inspire new approaches to achieving cavitation control in water, tissue and a variety of other media.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/j.ultrasmedbio.2020.12.007DOIArticle
ORCID:
AuthorORCID
Mancia, Lauren0000-0003-4366-1944
Rodriguez, Mauro0000-0003-0545-0265
Additional Information:© 2021 Elsevier. Received 23 May 2020, Revised 1 October 2020, Accepted 10 December 2020, Available online 7 January 2021.
Subject Keywords:Cavitation; Nucleation; Intrinsic threshold; Bubble dynamics; Histotripsy; Focused ultrasound
Issue or Number:4
Record Number:CaltechAUTHORS:20210120-152754721
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20210120-152754721
Official Citation:Lauren Mancia, Mauro Rodriguez, Jonathan R. Sukovich, Scott Haskel, Zhen Xu, Eric Johnsen, Acoustic Measurements of Nucleus Size Distribution at the Cavitation Threshold, Ultrasound in Medicine & Biology, Volume 47, Issue 4, 2021, Pages 1024-1031, ISSN 0301-5629, https://doi.org/10.1016/j.ultrasmedbio.2020.12.007. (https://www.sciencedirect.com/science/article/pii/S0301562920305639)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:107606
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:21 Jan 2021 00:22
Last Modified:16 Feb 2021 18:21

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